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Protective potentials of ethyl acetate-ethanolic fraction of Carica papaya leaves against acetaminophen-induced liver damage in rats

Hussein O. B. Oloyede, Halimat Y. Lukman, Musa O. Salawu
Notulae Scientia Biologicae , Volume 12, pp 556-567; doi:10.15835/nsb12310629

Abstract: The liver is an important organ performing vital roles that become affected when damaged. The protective potential of ethyl acetate-ethanolic fraction of Carica papaya leaves on acetaminophen-induced liver damage in female albino rats was investigated. Forty female rats were completely randomized into eight groups (A-H) of five rats each. Group A (control), received 1 ml of distilled water, group B (untreated) received 250 mgkg-1 bw of acetaminophen, group C received silymarin (50 mgkg-1 bw) followed by actaminophen (250 mgkg-1 bw), groups D-G received 100, 200, 400 and 600 mgkg-1 bw of ethyl acetate-ethanolic fraction of Carica papaya leaves respectively; followed by acetaminophen administration (250 mgkg-1 bw), while group H (toxicity control) received 600 mgkg-1 bw extract fraction daily. Ethyl acetate-ethanolic fraction of Carica papaya leaves significantly (p
Keywords: acetaminophen / Carica papaya / ethyl acetate / Papaya Leaves / Acetate Ethanolic / Ethanolic Fraction

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