Methylprednisolone in acute respiratory distress-syndrome in COVID-19: rationales for use, optimal dosage regimens, combined use with tocilizumab
Open Access
- 28 October 2020
- journal article
- Published by Publishing House OKI in Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice
- No. 4S,p. 23-27
- https://doi.org/10.37489/2588-0519-2020-s4-23-27
Abstract
No robust evidence proving clinical effectiveness of methylprednisolone in acute respiratory distress-syndrome in COVID-19, including combined use with tocilizumab, has been identified. Systemic glucocorticosteroids use may be considered acceptable in such patients in life-threatening situations, when interleukin-6 blockers (tocilizumab, sarilumab) are unavailable.Keywords
This publication has 14 references indexed in Scilit:
- Early, low-dose and short-term application of corticosteroid treatment in patients with severe COVID-19 pneumonia: single-center experience from Wuhan, ChinaPublished by Cold Spring Harbor Laboratory ,2020
- Clinical features and progression of acute respiratory distress syndrome in coronavirus disease 2019Published by Cold Spring Harbor Laboratory ,2020
- On the use of corticosteroids for 2019-nCoV pneumoniaThe Lancet, 2020
- Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injuryThe Lancet, 2020
- Corticosteroid Therapy for Critically Ill Patients with Middle East Respiratory SyndromeAmerican Journal of Respiratory and Critical Care Medicine, 2018
- Cytokine storm and sepsis disease pathogenesisSeminars in Immunopathology, 2017
- Pulmonary Involvement in Patients With Hemophagocytic LymphohistiocytosisSocial psychiatry. Sozialpsychiatrie. Psychiatrie sociale, 2016
- Corticosteroids as adjunctive therapy in the treatment of influenzaEmergencias, 2016
- Prolonged glucocorticoid treatment is associated with improved ARDS outcomes: analysis of individual patients’ data from four randomized trials and trial-level meta-analysis of the updated literatureIntensive Care Medicine, 2015
- SARS: Systematic Review of Treatment EffectsPLoS Medicine, 2006