Effect of tetracyclines on pulpal and periodontal healing after tooth replantation: a systematic review of human and animal studies
Open Access
- 5 June 2021
- journal article
- review article
- Published by Springer Science and Business Media LLC in BMC Oral Health
- Vol. 21 (1), 1-14
- https://doi.org/10.1186/s12903-021-01615-y
Abstract
Background Pulpal and periodontal healing are two main concerns of delayed replantation of avulsed teeth. The objective of this review was to evaluate the effectiveness of topical and systemic application of tetracyclines on pulpal and periodontal healing after tooth replantation. Methods A comprehensive electronic search was conducted in six databases. This systematic review was carried out according to Cochrane Handbook and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Results After exclusion of 246 irrelevant papers, 14 animal studies and one human study were included in this review. The human study showed that avulsed permanent teeth treated with doxycycline did not show a better clinical outcome for pulp and periodontal healing compared with treatment with normal saline. As for animal studies, significant more pulpal healing was observed in immature teeth treated with topical doxycycline in two researches, while another one study showed that there is no difference between teeth treated with normal saline and teeth treated with doxycycline. Systemic doxycycline exerted no significant effect on pulpal revascularization illustrated by one research. Only one out of four articles illustrated the positive effect of systemic tetracyclines on periodontal healing. One paper reported that intracanal application of demeclocycline promoted favorable periodontal healing. Two articles showed topical doxycycline contributed to favorable periodontal healing, while five studies showed no significant effect of topical tetracyclines on periodontal healing. Conclusions As a result of data heterogeneity and limitations of the studies, the effect of topical or systemic application of tetracyclines on pulpal and periodontal healing is inconclusive. More studies are required to get more clinically significant conclusions.Keywords
This publication has 72 references indexed in Scilit:
- Efficacy of subantimicrobial-dose doxycycline against nitrosative stress in chronic periodontitisActa Pharmacologica Sinica, 2012
- Non-antibacterial tetracycline formulations: clinical applications in dentistry and medicineJournal of Oral Microbiology, 2012
- A study of the clinical activity of a gel combining monocaprin and doxycycline: a novel treatment for herpes labialisJournal of Oral Pathology & Medicine, 2011
- A retrospective study of 889 injured permanent teethDental Traumatology, 2010
- Factors related to treatment and outcomes of avulsed teethDental Traumatology, 2010
- The effect of intracanal anti‐inflammatory medicaments on external root resorption of replanted dog teeth after extended extra‐oral dry timeDental Traumatology, 2007
- Replantation of 400 avulsed permanent incisors. 3. Factors related to root growthDental Traumatology, 1995
- Effect of stannous fluoride and tetracycline on periodontal repair after delayed tooth replantation in dogsEuropean Journal of Oral Sciences, 1992
- Effect of tetracycline and SnF2on root resorption in replanted incisors in dogsEuropean Journal of Oral Sciences, 1989
- Tetracycline and Its Derivatives Strongly Bind to and Are Released From the Tooth Surface in Active FormThe Journal of Periodontology, 1983