Sales trends of psychotropic drugs in the COVID-19 pandemic: A national database study in Brazil
Open Access
- 17 March 2023
- journal article
- research article
- Published by Frontiers Media SA in Frontiers in Pharmacology
- Vol. 14, 1131357
- https://doi.org/10.3389/fphar.2023.1131357
Abstract
[Background]: The social restrictions among coronavirus disease 2019 (COVID-19) pandemic have posed a thoughtful risk to mental health and have implications in the use of drugs, including antidepressants, anxiolytics and other psychotropics. [Objective]: This study analyzed the sales data of the psychotropics prescribed in Brazil, in order to verify the change in consumption trends of these drugs during the COVID-19 pandemic. [Methods]: This interrupted time-series analyzed psychotropic sales data, between January 2014 and July 2021, using the National System of Controlled Products Management from The Brazilian Health Regulatory Agency. The monthly mean DDDs per 1,000 inhabitants per day of psychotropic drugs was evaluated by analysis of variance (ANOVA) followed by Dunnett Multiple Comparisons Test. The changes in monthly trends in the use of the psychotropic studied were evaluated by Joinpoint regression. [Results]: During the period studied, clonazepam, alprazolam, zolpidem and escitalopram were the most sold psychotropic drugs in Brazil. According to Joinpoint regression, an upward trend was observed in sales during the pandemic of pregabalin, escitalopram, lithium, demvefaxine, citalopram, buproprion and amitriptyline. An increase in psychotropic consumption was noted throughout the pandemic period, with the maximum consumption (2.61 DDDs) occurring in April 2021, with a downward trend in consumption that accompanied the drop in the number of deaths. [Conclusions]: The increase in sales, mainly of antidepressants during the COVID-19 pandemic, draws attention to issues related to the mental health of the Brazilian population and on the need for greater monitoring in the dispensing of these drugs.This publication has 37 references indexed in Scilit:
- COVID-19, lockdowns and well-being: Evidence from Google TrendsJournal of Public Economics, 2020
- Factors Associated With Mental Health Disorders Among University Students in France Confined During the COVID-19 PandemicJAMA Network Open, 2020
- COVID-19 pandemic and mental health consequences: Systematic review of the current evidenceBrain, Behavior, and Immunity, 2020
- Prevalence of Depression Symptoms in US Adults Before and During the COVID-19 PandemicJAMA Network Open, 2020
- Covid‐19 health crisis and lockdown associated with high level of sleep complaints and hypnotic uptake at the population levelJournal of Sleep Research, 2020
- Is the lockdown important to prevent the COVID-19 pandemic? Effects on psychology, environment and economy-perspectiveAnnals of Medicine & Surgery, 2020
- Alcohol consumption in the COVID-19 eraMinerva Gastroenterologica E Dietologica, 2020
- Psychosocial impact of COVID-19Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 2020
- The psychological impact of quarantine and how to reduce it: rapid review of the evidenceThe Lancet, 2020
- Consumo de álcool durante a pandemia da COVID-19: uma reflexão necessária para o enfrentamento da situaçãoCadernos de Saude Publica, 2020