SARS-CoV-2 infection and phylogenetic analysis with the risk factors in human body alongside the pulmonary effects and medication
Open Access
- 6 November 2020
- journal article
- Published by Heighten Science Publications Corporation in Insights in Biology and Medicine
- Vol. 4 (1), 023-029
- https://doi.org/10.29328/journal.ibm.1001018
Abstract
Related the extremely transmittable abilities of SARS-CoV-2,a harmonious virus to the bat CoV, gets transmitted by three principal processes-- the inhalation of droplets from the SARS-CoV-2 infected person, contacting to the person, and by the surfaces and materials defiled with the virus. Whereupon bat Coronavirus is mostly like the pandemic causing virus SARS-CoV-2, bats are often deliberated and figured out as a possible primary host although no intermediate has not been defined yet in the wherewithal of transmission. The Spike Glycoprotein plays an important role in the case of penetration with the assistance of the ACE2 receptor and the Receptor Binding Domain. In the human body, infiltrating the nucleic acid into host cells, SARS-CoV-2 attacks one cell and one by one into the whole human body; therefore, infected cases are found symptomatic and asymptomatic considering the immune power. Patients with cardiovascular disease or diabetes proceed with their treatment with ACE2 often; therefore, there might be a high chance of getting infected. Whereas the SARS-CoV-2 infects the blood and then lungs, Antigens improvement can be better in order to avoid high-complicated effects. Currently, no vaccination or no accurate cure and treatment has not been defined. An explanation with analysis on SARS-CoV-2 has been performed from the aspect of virology, immunology and molecular biology. Several relevant figures have been included hereby in order to a better understanding of the very concept.Keywords
This publication has 23 references indexed in Scilit:
- Immune mechanisms of pulmonary intravascular coagulopathy in COVID-19 pneumoniaThe Lancet Rheumatology, 2020
- Phylogenetic Analysis and Structural Modeling of SARS-CoV-2 Spike Protein Reveals an Evolutionary Distinct and Proteolytically Sensitive Activation LoopJournal of Molecular Biology, 2020
- Coronavirus Diseases (COVID-19) Current Status and Future Perspectives: A Narrative ReviewInternational Journal of Environmental Research and Public Health, 2020
- High population densities catalyse the spread of COVID-19Journal of Travel Medicine, 2020
- Defining the Epidemiology of Covid-19 — Studies NeededThe New England Journal of Medicine, 2020
- COVID-19 infection: Emergence, transmission, and characteristics of human coronavirusesJournal of Advanced Research, 2020
- Transmission interval estimates suggest pre-symptomatic spread of COVID-19Published by Cold Spring Harbor Laboratory ,2020
- Another Decade, Another CoronavirusThe New England Journal of Medicine, 2020
- A pneumonia outbreak associated with a new coronavirus of probable bat originNature, 2020
- Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patientsEmerging Microbes & Infections, 2020