G-proteins (Gi, Go) in the basal ganglia of control and schizophrenic brain
- 1 October 1990
- journal article
- research article
- Published by Springer Science and Business Media LLC in Journal of Neural Transmission
- Vol. 79 (3), 227-234
- https://doi.org/10.1007/bf01245133
Abstract
Summary We detected the existence of Gi (the inhibitory G-protein) or Go (a similar G-protein of unknown function) in the striatum of control and schizophrenic brains utilizing pertussis toxin-catalyzed ADP ribosylation. The level of Gi/Go was significantly decreased by 42% in the putamen of the left hemisphere in schizophrenics; caudate head and globus pallidus levels were unchanged. Decreased Gi or Go may underlie enhanced dopamine function in the schizophrenic brain.Keywords
This publication has 33 references indexed in Scilit:
- Guanine nucleotide-binding regulatory proteins; mediators of transmembrane signalingTrends in Pharmacological Sciences, 1987
- The human genome encodes at least three non‐allellic G proteins with αi‐type subunitsFEBS Letters, 1987
- A new GTP‐binding protein in brain tissues serving as the specific substrate of islet‐activating protein, pertussis toxinFEBS Letters, 1987
- Clinical Implications of Guanine Nucleotide–Binding Proteins as Receptor–Effector CouplersThe New England Journal of Medicine, 1985
- Islet-activating protein, pertussis toxin: a probe for functions of the inhibitory guanine nucleotide regulatory component of adenylate cyclaseTrends in Pharmacological Sciences, 1984
- G proteins and dual control of adenylate cyclaseCell, 1984
- Increased concentrations and lateral asymmetry of amygdala dopamine in schizophreniaNature, 1983
- Opposing roles for D-1 and D-2 dopamine receptors in efflux of cyclic AMP from rat neostriatumNature, 1981
- INCREASED DOPAMINE-RECEPTOR SENSITIVITY IN SCHIZOPHRENIAThe Lancet, 1978
- Drugs, Neurotransmitters, and SchizophreniaScience, 1974