A Novel Targeting Drug Delivery System Based on Self-Assembled Peptide Hydrogel
Open Access
- 1 January 2011
- journal article
- Published by Scientific Research Publishing, Inc. in Journal of Biomaterials and Nanobiotechnology
- Vol. 02 (05), 622-625
- https://doi.org/10.4236/jbnb.2011.225074
Abstract
In the last two decades, 5-fluorouracil (5-FU) is widely used in clinical practice to inhibit the fibroblasts to proliferate and improve the success rate of glaucoma-filtering surgery, but 5-FU has many toxic effects to normal ocular tissues. The self-assembled peptide hydrogels may serve as a new class of biomaterials for applications including tissue engineering and drug delivery. How to deliver 5-FU quickly and precisely to the target sites of ocular tissue by a self-assembled peptide hydrogel remains unexplored. RGD (arginine-glycine-aspartic acid) sequence is cell attachment site in extracellular matrix (ECM). Thus, If the self-assembled peptide hydrogel containing the RGD sequence that act as a specific attachment site for the proliferated fibroblasts adhesion could be designed, after integrated 5-FU, a novel targeting drug delivery system will be put into practice in the futureKeywords
This publication has 20 references indexed in Scilit:
- Self-assembled prodrugs: An enzymatically triggered drug-delivery platformBiomaterials, 2009
- d-Glucosamine-based supramolecular hydrogels to improve wound healingChemical Communications, 2006
- Self-Assembling Peptide as a Potential Carrier of Hydrophobic CompoundsJournal of the American Chemical Society, 2004
- Selective Differentiation of Neural Progenitor Cells by High-Epitope Density NanofibersScience, 2004
- Fabrication of novel biomaterials through molecular self-assemblyNature Biotechnology, 2003
- A reevaluation of integrins as regulators of angiogenesisNature Medicine, 2002
- Alterations in Fibroblast α1β1 Integrin Collagen Receptor Expression in Keloids and Hypertrophic ScarsJournal of Investigative Dermatology, 2002
- Hydrogels for Tissue EngineeringChemical Reviews, 2001
- The Evolution of Cell AdhesionThe Journal of cell biology, 2000
- Intraoperative Mitomycin versus Postoperative 5-Fluorouracil in High-risk Glaucoma Filtering SurgeryOphthalmology, 1992