l-Citrulline Supports Vascular and Muscular Benefits of Exercise Training in Older Adults
- 1 July 2020
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Exercise and Sport Sciences Reviews
- Vol. 48 (3), 133-139
- https://doi.org/10.1249/jes.0000000000000223
Abstract
Age-associated reduction in endothelial nitric oxide (NO) synthesis contributes to the development of cardiovascular diseases and sarcopenia. l-Citrulline is a precursor of NO with the ability to improve vascular function and muscle protein synthesis. We hypothesize that vascular and muscular benefits associated with oral l-citrulline supplementation might be augmented by concomitant supplementation with exercise training in older adults.Keywords
This publication has 48 references indexed in Scilit:
- Mechanisms Involved in the Aging-Induced Vascular DysfunctionFrontiers in Physiology, 2012
- Leucine and citrulline modulate muscle function in malnourished aged ratsAmino Acids, 2011
- Aging and vascular endothelial function in humansClinical Science, 2011
- Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old ratsJournal of Applied Physiology, 2009
- Pharmacokinetic and pharmacodynamic properties of oral L‐citrulline and L‐arginine: impact on nitric oxide metabolismBritish Journal of Clinical Pharmacology, 2007
- Dose-ranging effects of citrulline administration on plasma amino acids and hormonal patterns in healthy subjects: the Citrudose pharmacokinetic studyBritish Journal of Nutrition, 2007
- Citrulline modulates muscle protein metabolism in old malnourished ratsAmerican Journal of Physiology-Endocrinology and Metabolism, 2006
- Citrulline increases arginine pools and restores nitrogen balance after massive intestinal resectionGut, 2004
- Nitric Oxide in Skeletal Muscle: Inhibition of Nitric Oxide Synthase Inhibits Walking Speed in RatsNitric Oxide, 2001
- A comparison of the effects of vasodilator stimuli on peripheral resistance vessels in normal subjects and in patients with congestive heart failureJCI Insight, 1968