Kafeste Tutulan Yabani Kedigillerde Ketamin-Ksilazin İle İndüklenen Sedasyon Antagonizmi İçin Yohimbin ve Tolazolinin Karşılaştırmalı Etkinliği
- 1 January 2021
- journal article
- research article
- Published by Kafkas University in Kafkas Universitesi Veteriner Fakultesi Dergisi
- Vol. 27 (3), 291-299
- https://doi.org/10.9775/kvfd.2020.25124
Abstract
This study was conducted to investigate the comparative efficacy of yohimbine and tolazoline for antagonism of ketamine-xylazine induced sedation in captive wild felids in Pakistan. It included 16 tigers (Panthera tigris), 22 lions (Panthera leo) and 16 leopards (Panthera pardus), aged between 2-10 years, weighing approximately 190.6 +/- 12.4 kg, 161.6 +/- 16.6 kg, and 50.5 +/- 6.9 kg respectively. A total of 54 anesthetic inductions were carried out on clinical patients from all species dividing them into two groups KX-T and KX-Y receiving 0.15 mg/kg tolazoline and 0.15 mg/kg yohimbine as antagonists, respectively. Body temperature, pulse and respiration rate (TPR) were recorded at ten-minute intervals for thirty minutes in either groups. These physiological norms differed significantly only in Tigers at 10min and 20min intervals. Furthermore, onset of arousal and recovery time in animals receiving yohimbine was evidently shorter, ranging between 2.8 +/- 0.76 to 8.42 +/- 0.33 min. ALT, AST, Urea and Creatinine were significantly elevated in groups administered with Tolazoline when compared to Yohimbine as well. Hence, yohimbine at described dosage effectively antagonized ketamine and xylazine anesthesia by significant reduction in reversal times for all the species under consideration, bearing nominal deleterious effects on physiological, hepatic and renal parameters. So, this study concludes yohimbine to be a superior antagonist for ketamine-xylazine anesthetic reversal than tolazoline.Keywords
This publication has 14 references indexed in Scilit:
- Xylazine-ketamine immobilization and propofol anesthesia for surgical excision of sebaceous adenoma in a jaguar (Panthera onca)Veterinary World, 2014
- A landscape-based conservation strategy to double the wild tiger populationConservation Letters, 2011
- Current role of dexmedetomidine in clinical anesthesia and intensive careAnesthesia: Essays and Researches, 2011
- Pharmacological Aspects and Potential New Clinical Applications of Ketamine: Reevaluation of an Old DrugThe Journal of Clinical Pharmacology, 2009
- Tolazoline antagonises ketamine–xylazine anaesthesia in an endangered Black buck (Antilope cervicapra)European Journal of Wildlife Research, 2009
- Yohimbine antagonizes the anaesthetic effects of ketamine-xylazine in captive Indian wild felidsVeterinary Anaesthesia and Analgesia, 2009
- Safety, pharmacokinetics and use of the novel NK‐1 receptor antagonist maropitant (CereniaTM) for the prevention of emesis and motion sickness in catsJournal of Veterinary Pharmacology and Therapeutics, 2008
- Anesthetic and physiologic effects of tiletamine, zolazepam, ketamine, and xylazine combination (TKX) in feral cats undergoing surgical sterilizationJournal of Feline Medicine and Surgery, 2004
- Human Population Density and Extinction Risk in the World's CarnivoresPLoS Biology, 2004
- Inventory of free-ranging lions Panthera leo in AfricaOryx, 2004