Label-free non-invasive subwavelength-resolution imaging using yeast cells as biological lenses
- 26 October 2021
- journal article
- research article
- Published by Optica Publishing Group in Biomedical Optics Express
- Vol. 12 (11), 7113-7121
- https://doi.org/10.1364/boe.437965
Abstract
There is a growing interest to use live cells to replace the widely used non-biological microsphere lenses. In this work, we demonstrate the use of yeast cells for such imaging purpose. Using fiber-based optical trapping technique, we trap a chain of three yeast cells and bring them to the vicinity of imaging objects. These yeast cells work as near-field magnifying lenses and simultaneously pick up the sub-diffraction information of the nanoscale objects under each cell and project them into the far-field. The experimental results demonstrated that Blu-ray disc of 100 nm feature can be clearly resolved in a parallel manner by each cell. (c) 2021 Optical Society of America under the terms of the OSA Open Access Publishing AgreementKeywords
Funding Information
- Natural Science Foundation of Heilongjiang Province (LH2021F008)
- Welsh Government on Center for Photonics Expertise (CPE) Project (81400)
- European Regional Development Fund
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