Plasma Native Thiol and Lipid Hydroperoxide Levels in the Patients with A Non-Aura Migraine Attack Admitted to the Emergency Department: A Case- Control Study

Abstract

Aim: We emphasize the importance of serum native thiol (SH), lipid peroxidation (LOOH), and ceruloplasmin (CP) levels in the management of patients with a migraine attack and clarify the possible relationships among these parameters in the emergency department (ED) Methods: The study was designed as a case-control study which is a type of observational study by including the patients who applied to the University of Health Sciences Turkey, University Diyarbakir Gazi Yasargil Training and Research Hospital between December 2018 and July 2019. A total of 88 participants (study group, n=46 and healthy control group, n=42) consecutively admitted to the ED. with similar demographic characteristics were included in the study. SH, LOOH, and CP levels in both groups were recorded and studied. Results: The serum SH level was significantly lower in the patient than in the control group (p=0.002). However, the LOOH and CP levels were significantly higher in the patient group than in the control group (p<0.001). A significant correlation was observed between LOOH and CP (r=0.332, p=0.002). The receiver operating characteristic analysis indicated that a serum LOOH level of 11.9 mu mol/L predicted an acute migraine attack with 89% sensitivity and 71% specificity. Conclusions: Our results suggest that the oxidative status is activated in patients with a non-aura migraine attack, and this may lead to other oxidative and inflammatory processes, with an increase in the serum LOOH level and a decrease in the native thiol level.