Synthesis, structural and spectral characterization, and in vitro nuclease activity of new thiosemicarbazone derivatives
Open Access
- 31 March 2016
- journal article
- Published by European Journal of Chemistry in European Journal of Chemistry
- Vol. 7 (1), 1-7
- https://doi.org/10.5155/eurjchem.7.1.1-7.1354
Abstract
Two new compounds, (E)-2-(3-ethoxy-2-hydroxybenzylidene)hydrazinecarbothioamide (1) and (E)-N-ethyl-2-((2-hydroxynaphthalen-1-yl)methylene)hydrazinecarbothioamide (2) have been synthesized. The prepared compounds have been characterized by CHN analysis, FT-IR, UV-Vis, 1H and 13C NMR spectroscopic techniques as well as the fluorescence emission spectroscopy. The molecular structures of the compounds have also been determined by X-ray single crystal diffraction analysis. The crystal structures revealed that the compounds are remain as a thione form in the solid state and are different in their geometrical, conformational and symmetrical structures. The nuclease activity of compounds to cleave pBR 322 has been investigated using agarose gel electrophoresis assay. The compound 2 revealed a significant nuclease activity which was attributed to the lipophilic properties that provided by substituent moieties of the compound.Keywords
This publication has 30 references indexed in Scilit:
- Asynthesis, Crystal Structures and in Vitro Anticancer Studies of New Thiosemicarbazone DerivativesPhosphorus, Sulfur, and Silicon and the Related Elements, 2015
- Synthesis and characterization of thiosemicarbazonato molybdenum(VI) complexes: In vitro DNA binding, cleavage, and antitumor activitiesPolyhedron, 2015
- Synthesis of copper(II) complexes of isatin thiosemicarbazone derivatives: In vitro anti-cancer, DNA binding, and cleavage activitiesPolyhedron, 2014
- Microwave-assisted synthesis and antioxidant properties of hydrazinyl thiazolyl coumarin derivativesChemistry Central Journal, 2012
- Dinuclear and polynuclear dioxomolybdenum(VI) Schiff base complexes: Synthesis, structural elucidation, spectroscopic characterization, electrochemistry and catalytic propertyPolyhedron, 2012
- Synthesis, Activity Testing and Molybdenum(VI) Complexation of Schiff Bases Derived from 2,4,6-Trihydroxybenzaldehyde Investigated as Xanthine Oxidase InhibitorsChemMedChem, 2010
- Gallium(III) complexes of 2-pyridineformamide thiosemicarbazones: Cytotoxic activity against malignant glioblastomaEuropean Journal of Medicinal Chemistry, 2009
- Complexes of 2-acetyl-γ-butyrolactone and 2-furancarbaldehyde thiosemicarbazones: Antibacterial and antifungal activityJournal of Inorganic Biochemistry, 2009
- Gallium(III) and Iron(III) Complexes of α-N-Heterocyclic Thiosemicarbazones: Synthesis, Characterization, Cytotoxicity, and Interaction with Ribonucleotide ReductaseJournal of Medicinal Chemistry, 2007
- New methyl pyruvate thiosemicarbazones and their copper and zinc complexes: synthesis, characterization, X-ray structures and biological activityJournal of Inorganic Biochemistry, 2001