Over the past three decades, various countries and stakeholders have aimed at having cities that can better handle natural and human-made disasters, protect human life, absorb the impact of economic, environmental and social hazards and promote well-being, inclusive and sustainable growth. This paper investigates how informal ties result in in-filling and the creation of slums in the context of efforts to make cities resilient in Ghana using the Accra Metropolis as case study. The United Nations Habitat classification of slums was used to purposively select two slum settlements in Accra for the study. The study used mixed methods of quantitative and qualitative approaches to collect data from April 2018 to August 2018. Quantitative data was collected from 400 slum dwellers while qualitative data was collected from eight focus group discussion sessions and in-depth interviews with at least one senior official from related institutions such as Accra Metropolitan Assembly (AMA), Ministry of Local Government and Rural Development (MLGRD), Ministry of Water Resources (MWR), Ministry of Works and Housing (MWH), Ministry of Inner City and Zongo Development (MICZD), Environmental Protection Agency (EPA), Ghana Police Service, and Ghana National Fire Service. Descriptive techniques were used for the analysis. The findings are that informal ties contribute to in-filling in slums. Slum dwellers do not plan to return home, they are not involved in land use decision making and the slums have opportunities and challenges to the slum dwellers and AMA. The AMA should avoid forced eviction of slums and rather enforce development control bye-laws, implement slum upgrading programs, and involve slum dwellers in upgrading programs. Slum dwellers must cooperate with AMA to make Accra resilient. The mainstreaming of the issue of slums in all urban development agendas needs to be given the needed political and policy attention by central government and all stakeholders.