Investigation on Anti-Ulcer Activity of Momordica dioica Fruits in Wistar Rat

Abstract

To present study was carried out to investigate antiulcer activity of Ethanolic extract of Momordica dioica fruits in pylorus ligatated and Cold stress induced ulceration in the wistar rats. Pylorus ligation induced ulcer is one of the most widely used methods for studying the effect of drug on gastric secretion. Effect of distilled water in pylorus ligation has caused the accumulation of gastric sectretion and decreased the pH. Ranitidine and Ethanolic extracts of Momordica dioica significantly decreased the gastric volume, total acidity, free acidity, ulcer score, number of ulcer and ulcer index and raise the pH (shown in graph. 1, 2, 3, 4, 5, 6,).Similar studies support our results. Ethanolic extract of Momordica dioica at a dose of (400mg/kg. p.o) showed significant inhibition of ulcerative lesion by 46.33% and 54.66%, respectively, as compared to the control value The Ethanol extract of Momordica dioica fruits possess significant antiulcer properties in a dose dependent manner.