Synthesis, reactions and biological evaluation of some novel thienothiophene derivatives
Open Access
- 30 September 2019
- journal article
- Published by European Journal of Chemistry in European Journal of Chemistry
- Vol. 10 (3), 209-217
- https://doi.org/10.5155/eurjchem.10.3.209-217.1850
Abstract
Synthesis of some new bis(chalcones)-based thienothiophene derivatives and study of their synthetic utilities as building blocks for new bis(thiazole), bis(dihydropyran), bis(dihydro pyridine), bis(isoxazoles), bis(pyrazoles), bis(hydropyrimidinethiones), bis(tetrahydro diazepines, oxazepines) and bis(dihydrobenzodiazepnies, benzoxazepines) each linked to a thienothiophene core, is reported. Biological evaluation of the obtained compounds as antibacterial agents was achieved. Compounds 4b, 4c, 7a, 6a, 9a and 11b were found to be very potent against P. aeruginosa, E. coli and K. pneumonia.Keywords
This publication has 49 references indexed in Scilit:
- Chalcones as Versatile Synthons for the Synthesis of 5- and 6-membered Nitrogen HeterocyclesCurrent Organic Chemistry, 2014
- Recent developments in biological activities of chalcones: A mini reviewEuropean Journal of Medicinal Chemistry, 2014
- Recent Advances on the Synthesis of Chalcones with Antimicrobial Activities: A Brief ReviewLetters in Organic Chemistry, 2014
- Review of Methods and Various Catalysts Used for Chalcone SynthesisMini-Reviews in Organic Chemistry, 2013
- Synthesis, antioxidant and DNA cleavage activities of novel indole derivativesEuropean Journal of Medicinal Chemistry, 2010
- Synthesis and biological evaluation of indolyl chalcones as antitumor agentsBioorganic & Medicinal Chemistry Letters, 2010
- Synthesis and Chemical Characterisation of New Bis-Thieno [2,3-b]thiophene DerivativesMolecules, 2010
- Acid-catalyzed synthesis of oxathiolone fused chalcones. Comparison of their activity toward various microorganisms and human cancer cells lineEuropean Journal of Medicinal Chemistry, 2007
- Synthesis and biological evaluation of chalcones and their derived pyrazoles as potential cytotoxic agentsBioorganic & Medicinal Chemistry Letters, 2005
- Synthesis of 1,3,3a,5‐tetraaryl‐3a,4,5,6‐tetrahydro‐3H‐1,2,4‐triazolo[4,3‐a] [1,5]benzodiazepinesHeteroatom Chemistry, 2001