Synthesis and antibacterial activity of some new 1,2,4-triazole derivatives bearing carbohydrazide moiety
- 30 June 2020
- journal article
- Published by European Journal of Chemistry in European Journal of Chemistry
- Vol. 11 (2), 113-119
- https://doi.org/10.5155/eurjchem.11.2.113-119.1968
Abstract
In this study, a series of 1,2,4-triazol-3-carbohydrazide derivatives and compound of 1,2,4-triazole-3-(4H)-thion have been synthesized. Structures and purity of the new compounds were confirmed by the use of their chromatographic and spectral data besides microanalysis. Four different bacterial stains for the study of the biological activity of compounds 6g, 7c, 7g and 7i; two Gram-positive strains, and two Gram-negative strains have been used. Compound 6g was found to be the most active of the four tested compounds against Pseudomonas aeruginosa, Bacillus cereus and Staphylococcus aureus, with an inhibition zone diameter of 16, 9, and 10 mm, respectively. Calculating the minimal inhibitory concentration value (MIC) for the positive drugs who formed an inhibition zone in the agar well diffusion method, we found that both compounds 6g and 7i were the most active of the four tested compounds against Pseudomonas aeruginosa and Bacillus cereus with an MIC value of 0.5 µg/mL for both bacteria. These results suggest that these two compounds could be considered as potential antibacterial agents against a range of bacteria.Keywords
This publication has 39 references indexed in Scilit:
- Design, Synthesis, and Antifungal Activities of Novel 1,2,4‐Triazole Schiff Base DerivativesChemistry & Biodiversity, 2018
- Antibiotic resistance—the need for global solutionsThe Lancet Infectious Diseases, 2013
- Challenges of drug resistance in the developing worldBMJ, 2012
- Synthesis and structure–activity relationship studies of 4-arylthiosemicarbazides as topoisomerase IV inhibitors with Gram-positive antibacterial activity. Search for molecular basis of antibacterial activity of thiosemicarbazidesEuropean Journal of Medicinal Chemistry, 2011
- Synthesis and biological evaluation of dihydroindeno and indeno [1,2-e] [1,2,4]triazolo [3,4-b] [1,3,4]thiadiazines as antimicrobial agentsEuropean Journal of Medicinal Chemistry, 2011
- Design, synthesis, and docking studies of novel ofloxacin analogues as antimicrobial agentsMedicinal Chemistry Research, 2011
- Synthesis and antimicrobial activity evaluation of new 1,2,4-triazoles and 1,3,4-thiadiazoles bearing imidazo[2,1-b]thiazole moietyEuropean Journal of Medicinal Chemistry, 2009
- Synthesis and QSAR studies of novel triazole compounds containing thioamide as potential antifungal agentsBioorganic & Medicinal Chemistry, 2006
- Synthesis and antimicrobial activity of some 1,2,4-triazole-3-mercaptoacetic acid derivativesIl Farmaco, 2001
- Synthesis and analgesic activity of some triazoles and triazolothiadiazinesIl Farmaco, 1999