Restoring arm function with a soft robotic wearable for individuals with amyotrophic lateral sclerosis
- 1 February 2023
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science Translational Medicine
- Vol. 15 (681), eadd1504
- https://doi.org/10.1126/scitranslmed.add1504
Abstract
Despite promising results in the rehabilitation field, it remains unclear whether upper limb robotic wearables, e.g., for people with physical impairments resulting from neurodegenerative disease, can be made portable and suitable for everyday use. We present a lightweight, fully portable, textile-based, soft inflatable wearable robot for shoulder elevation assistance that provides dynamic active support to the upper limbs. The technology is mechanically transparent when unpowered, can quantitatively assess free movement of the user, and adds only 150 grams of weight to each upper limb. In 10 individuals with amyotrophic lateral sclerosis (ALS) with different degrees of neuromuscular impairment, we demonstrated immediate improvement in the active range of motion and compensation for continuing physical deterioration in two individuals with ALS over 6 months. Along with improvements in movement, we show that this robotic wearable can improve functional activity without any training, restoring performance of basic activities of daily living. In addition, a reduction in shoulder muscle activity and perceived muscular exertion, coupled with increased endurance for holding objects, highlight the potential of this device to mitigate the impact of muscular fatigue for patients with ALS. These results represent a further step toward everyday use of assistive, soft, robotic wearables for the upper limbs.Keywords
This publication has 37 references indexed in Scilit:
- The phenotypic variability of amyotrophic lateral sclerosisNature Reviews Neurology, 2014
- A survey on robotic devices for upper limb rehabilitationJournal of NeuroEngineering and Rehabilitation, 2014
- Proximal myopathy: diagnostic approach and initial managementHeart, 2013
- A Robust and Sensitive Metric for Quantifying Movement SmoothnessIEEE Transactions on Biomedical Engineering, 2011
- Test-Retest Reproducibility and Smallest Real Difference of 5 Hand Function Tests in Patients With StrokeNeurorehabilitation and Neural Repair, 2009
- Recovery plateau following stroke: Fact or fiction?Disability and Rehabilitation, 2006
- Prediction of energy expenditure from heart rate monitoring during submaximal exerciseJournal of Sports Sciences, 2005
- Adjustments to Zatsiorsky-Seluyanov's segment inertia parametersJournal of Biomechanics, 1996
- Anatomical Data for Analyzing Human MotionResearch Quarterly for Exercise and Sport, 1983
- “Mini-mental state”: A practical method for grading the cognitive state of patients for the clinicianJournal of Psychiatric Research, 1975