New aspects of anticoagulant therapy in atrial fibrillation in patients with renal dysfunction
Open Access
- 5 December 2020
- journal article
- Published by Silicea - Poligraf, LLC in Russian Journal of Cardiology
- Vol. 25 (11), 4175
- https://doi.org/10.15829/29/1560-4071-2020-4175
Abstract
Atrial fibrillation (AF) and chronic kidney disease (CKD) are common and interrelated diseases, the combination of which is associated with a poor prognosis. The efficacy and safety of direct oral anticoagulants (DOACs) used to prevent thromboembolic complications of AF may depend on renal function due to the specific pharmacokinetics of these drugs. This review considers current data on the role of kidneys in the pathogenesis of ischemic and bleeding events, methods of renal function assessment and related classification issues, as well as comparison of warfarin and DOAC therapy, in patients with AF and renal dysfunction of different stages based on the results of randomized controlled trials and actual clinical practice. DOAC use in the context of dynamic deterioration of renal function, supranormal renal function, and their effect on renal outcomes is discussed. International guidelines on anticoagulant therapy in AF and renal dysfunction were analyzed.Keywords
This publication has 76 references indexed in Scilit:
- Prevalence of Advanced Chronic Kidney Disease in Patients with Nonvalvular Atrial Fibrillation Hospitalized in Cardiology DepartmentsKardiologiia, 2020
- Management and 1‐Year Outcomes of Patients With Newly Diagnosed Atrial Fibrillation and Chronic Kidney Disease: Results From the Prospective GARFIELD‐AF RegistryJournal of the American Heart Association, 2019
- Pharmacotherapy for Atrial Fibrillation in Patients With Chronic Kidney Disease: Insights From ORBIT‐AFJournal of the American Heart Association, 2018
- Chronic kidney disease and arrhythmias: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies ConferenceEuropean Heart Journal, 2018
- eGFR and Albuminuria in Relation to Risk of Incident Atrial Fibrillation: A Meta-Analysis of the Jackson Heart Study, the Multi-Ethnic Study of Atherosclerosis, and the Cardiovascular Health StudyClinical Journal of the American Society of Nephrology, 2017
- Global Prevalence of Chronic Kidney Disease – A Systematic Review and Meta-AnalysisPLOS ONE, 2016
- Incident Atrial Fibrillation and Risk of End-Stage Renal Disease in Adults With Chronic Kidney DiseaseJournal of the American College of Cardiology, 2013
- The prevalence of and factors associated with chronic atrial fibrillation in Medicare/Medicaid-eligible dialysis patientsKidney International, 2012
- Prevalence of Atrial Fibrillation and Its Predictors in Nondialysis Patients with Chronic Kidney DiseaseClinical Journal of the American Society of Nephrology, 2010
- Close bidirectional relationship between chronic kidney disease and atrial fibrillation: The Niigata preventive medicine studyAmerican Heart Journal, 2009