New Search

Export article
Open Access

Mitigation of Pseudomonas syringae virulence by signal inactivation

, Anugraha Mathew, Christian Jenul, Tobias Kohler, Max Bär, , , Urs Stalder, Ya-Chu Hsieh,
Show More
Abstract: Pseudomonas syringae is an important plant pathogen of many valuable crops worldwide, with more than 60 identified pathovars. The phytotoxins produced by these organisms were related to the severity of the damage caused to the plant. An emerging strategy to treat bacterial infections relies on interference with their signaling systems. In this study, we investigated P. syringae pv. syringae, which produces the virulence factor mangotoxin that causes bacterial apical necrosis on mango leaves. A previously unknown signaling molecule named leudiazen was identified, determined to be unstable and volatile, and responsible for mangotoxin production. A strategy using potassium permanganate, compatible with organic farming, was developed to degrade leudiazen and thus to attenuate the pathogenicity of P. syringae pv. syringae.
Keywords: leudiazen / mangotoxin / virulence / pathogenicity / signaling / Pseudomonas syringae / syringae pv

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

Share this article

Click here to see the statistics on "Science Advances" .
References (36)
    Back to Top Top