Malathion is a widely used organophosphorous pesticide that a large number of population are undesirably exposing themselves to severe health risk due to taking up the contaminated foods, water and vegetables. The present study was aims to evaluate the chronic toxicity of orally administered low doses of malathion in rabbits based on the body weight loss and blood profile. The study was conducted on sixty male rabbits, non-adult male rabbits they were divided into three equal groups, thirty rabbits of each group. The rabbits were treated orally with different dose (5 and 15 mg/ kg/day) of malathion for thirty days. After treatment; body weight were recorded and blood samples were collected for blood profile analysis to investigate the health changes. Changes in total body weight in both treatment groups were showed reduction while total body weight in control group showed significant increase (p ≤0.5). The counts of WBC were showed significant increase in low and high dose respectively compared with control group. We concluded that malathion decrease body weight.