Synthesis and antioxidant evaluation of some new pyridines
Open Access
- 31 March 2015
- journal article
- Published by European Journal of Chemistry in European Journal of Chemistry
- Vol. 6 (1), 84-87
- https://doi.org/10.5155/eurjchem.6.1.84-87.1149
Abstract
One-pot condensation of malononitrile (1), 4-methylpentan-2-one (2), aryl carboxaldehyde (3a-f) and ammonium acetate in ethanol afforded 2-amino-5-isopropyl-4-(4-aryl)-6-methylnicotinonitriles (4a-f). The antioxidant activity of the new synthesized compounds was evaluated and the result showed all compound exhibited weak anti-oxidant activities.Keywords
This publication has 20 references indexed in Scilit:
- A Concise and Diversity-Oriented Strategy for the Synthesis of Benzofurans and Indoles via Ugi and Diels−Alder ReactionsJournal of Combinatorial Chemistry, 2005
- Design, Synthesis, and Antipicornavirus Activity of 1-[5-(4-Arylphenoxy)alkyl]-3-pyridin-4-ylimidazolidin-2-one DerivativesJournal of Medicinal Chemistry, 2005
- Multicomponent ReactionsPublished by Wiley ,2005
- 5-Substituted Derivatives of 6-Halogeno-3-((2-(S)-azetidinyl)methoxy)pyridine and 6-Halogeno-3-((2-(S)-pyrrolidinyl)methoxy)pyridine with Low Picomolar Affinity for α4β2 Nicotinic Acetylcholine Receptor and Wide Range of Lipophilicity: Potential Probes for Imaging with Positron Emission TomographyJournal of Medicinal Chemistry, 2004
- Recent Developments in the Isonitrile‐Based Multicomponent Synthesis of HeterocyclesEuropean Journal of Organic Chemistry, 2003
- “Multi-component Reactions : Emerging Chemistry in Drug Discovery” ‘From Xylocain to Crixivan’Current Medicinal Chemistry, 2003
- Practical Asymmetric Synthesis of an Endothelin Receptor AntagonistThe Journal of Organic Chemistry, 1999
- Synthesis, CoMFA Analysis, and Receptor Docking of 3,5-Diacyl-2,4-Dialkylpyridine Derivatives as Selective A3 Adenosine Receptor AntagonistsJournal of Medicinal Chemistry, 1999
- A practical synthesis of the 5-chloromethyl-furo[2,3-b]pyridine pharmacophoreTetrahedron Letters, 1995
- Heterocyclic analogs of the antihypertensive .beta.-adrenergic blocking agent (S)-2-[3-(tert-butylamino)-2-hydroxypropoxy]-3-cyanopyridineJournal of Medicinal Chemistry, 1980