Filamentous Bacteriophage—A Powerful Carrier for Glioma Therapy
Open Access
- 10 September 2021
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Immunology
Abstract
Glioma is a life-threatening malignant tumor. Resistance to traditional treatments and tumor recurrence present major challenges in treating and managing this disease, consequently, new therapeutic strategies must be developed. Crossing the blood-brain barrier (BBB) is another challenge for most drug vectors and therapy medications. Filamentous bacteriophage can enter the brain across the BBB. Compared to traditional drug vectors, phage-based drugs offer thermodynamic stability, biocompatibility, homogeneity, high carrying capacity, self-assembly, scalability, and low toxicity. Tumor-targeting peptides from phage library and phages displaying targeting peptides are ideal drug delivery agents. This review summarized recent studies on phage-based glioma therapy and shed light on the developing therapeutics phage in the personalized treatment of glioma.Funding Information
- Foundation for Innovative Research Groups of the National Natural Science Foundation of China
- Department of Science and Technology of Jilin Province
- Department of Finance of Jilin Province
- Education Department of Jilin Province
- National Key Research and Development Program of China (2018YFC1311600)
This publication has 110 references indexed in Scilit:
- A peptide-mediated targeting gene delivery system for malignant glioma cellsInternational Journal of Nanomedicine, 2013
- Bacteriophage Bionanowire as a Carrier for Both Cancer‐Targeting Peptides and Photosensitizers and its use in Selective Cancer Cell Killing by Photodynamic TherapySmall, 2012
- Expanding the Versatility of Phage Display I: Efficient Display of Peptide-Tags on Protein VII of the Filamentous PhagePLOS ONE, 2011
- A Cy5.5-labeled phage-displayed peptide probe for near-infrared fluorescence imaging of tumor vasculature in living miceAmino Acids, 2011
- In vivo characteristics of targeted drug-carrying filamentous bacteriophage nanomedicinesJournal of Nanobiotechnology, 2011
- Isolation of peptide ligands that interact specifically with human glioma cellsPeptides, 2010
- A peptide-based carrier for intracellular delivery of proteins into malignant glial cells in vitroJournal of Controlled Release, 2008
- Targeting Heat Shock Proteins on Cancer Cells: Selection, Characterization, and Cell-Penetrating Properties of a Peptidic GRP78 LigandBiochemistry, 2006
- Molecular Structure of fd (f1, M13) Filamentous Bacteriophage Refined with Respect to X-ray Fibre Diffraction and Solid-state NMR Data Supports Specific Models of Phage Assembly at the Bacterial MembraneJournal of Molecular Biology, 2006
- Combining phage display and screening of cDNA expression libraries: a new approach for identifying the target antigen of an scFv preselected by phage displayJournal of Molecular Biology, 2000