The First Live Birth in Lithuania After Application of Preimplantation Genetic Testing
Open Access
- 21 December 2020
- journal article
- Published by Vilnius University Press in Acta medica Lituanica
- Vol. 27 (2), 75-82
- https://doi.org/10.15388/amed.2020.27.2.5
Abstract
Background. Preimplantation genetic testing (PGT) is a genetic testing procedure that is performed before the implantation of embryos for the identification of genetic abnormalities. It is commonly performed when one or both expecting parents have such abnormalities and are at a high risk of passing them to their offspring. The aim of this case report is to describe the first successful IVF/ICSI/PGT procedure in Lithuania.Case report. A 27-year-old woman and a 31-year-old man, a married couple, were referred to VUHSK Santaros Fertility Center after trying to conceive for 4 years. In a previous relationship, the woman got pregnant spontaneously and decided to terminate the pregnancy. The husband does not have any children. During the medical examination, the transvaginal ultrasound revealed a low antral follicle count and low anti-Müllerian hormone level for the woman. Semen analysis for the male patient showed severe oligoastenospermia, which confirmed the previous abnormal spermogram results. Chromosome analysis revealed normal karyotype for the woman (46,XX) and Robertsonian translocation for the husband (45,XY,der(13;14)(q10;q10)). After the interdisciplinary medical team counselling, an ICSI with PGT-SR was suggested for the couple. The woman underwent controlled ovarian hyperstimulation with GnRH antagonist protocol for 11 days. Only one embryo with no unbalanced rearrangements was identified and transferred to the woman. On the 14th day post oocyte retrieval, the first serum β-hCG result was received – 39.5 mIU/ml, and the normal gestational sac at 5 weeks and 3 days was confirmed by ultrasound examination.Conclusion: the first successful pregnancy was achieved in Lithuania and the first IVF/ICSI/PGT-SR newborn in Lithuania was born in 2019 – a vaginal birth of a healthy girl with gestational age of 38 weeks and 4 days and a weight of 2820 g; the Apgar score was 10/10. The IVF/ICSI/PGT procedure was successfully implemented by the multidisciplinary team in VUHSK.Keywords
This publication has 16 references indexed in Scilit:
- Preimplantation genetic diagnosis and screening: Current status and future challengesJournal of the Formosan Medical Association, 2018
- The International Glossary on Infertility and Fertility Care, 2017†‡§Human Reproduction, 2017
- ESHRE Task Force on Ethics and Law22: Preimplantation Genetic DiagnosisHuman Reproduction, 2014
- Clinical Management of in Vitro Fertilization with Preimplantation Genetic DiagnosisSeminars in Reproductive Medicine, 2012
- ESHRE consensus on the definition of 'poor response' to ovarian stimulation for in vitro fertilization: the Bologna criteriaHuman Reproduction, 2011
- Human chorionic gonadotrophin regulates FGF2 and other cytokines produced by human endometrial epithelial cells, providing a mechanism for enhancing endometrial receptivityHuman Reproduction, 2011
- Does blastomere biopsy in preimplantation genetic diagnosis affect early serum β-hCG levels?Clinical and Experimental Reproductive Medicine, 2011
- The management of infertility due to obstructive azoospermiaFertility and Sterility, 2008
- Human trophectoderm biopsy and secretion of chorionic gonadotrohinHuman Reproduction, 1991
- Human trophectoderm biopsy and secretion of chorionic gonadotrophin.1991