PREDICTIVE GENETIC SIGNS OF INTRAUTERINE GROWTH RETARDATION SYNDROM IN NEWBORNS

Abstract

The influence of genetically determined factors of mutation genetic pressing leads to genetic instability increasing or reducing genom’s sensitivenes to further mutant action, which is of major importance in developing the syndrome of intrauterine growth retardation (IUGR) in newborns. The main markers of genetic instability are the changes in morphological cell characteristics (cytogenetic, cytological, cytodensimetric), polymorphism of genes of xenobiotics detoxication GSTM1 and GSTТ1, changes in enzyme activity of glutathione acid and oxidation protein modification. In order to define the leading factors of destruction of genetic status of newborns with IUGR syndrome a discriminant and correlation analysis was conducted, which determined the links between the genes of xenobiotics detoxication GSTM1 and GSTТ1, by the indices of morphological functional genome state, enzymes activity of glutathione system and oxidation protein modifications and development of IUGR syndrome. The model of the statistic analysis of cytogenic, molecular genetic and biochemical characteristics enables to obtain an objective characteristic of the state of inheritance apparatus of newborns with IGR in comparison with healthy newborns.