Perinatal outcomes of high-dose vitamin D administration in the last trimester
Open Access
- 2 June 2021
- journal article
- research article
- Published by Galenos Yayinevi in Journal of Turkish Society of Obstetric and Gynecology
- Vol. 18 (2), 159-162
- https://doi.org/10.4274/tjod.galenos.2021.90023
Abstract
In recent years, interest in the evaluation of vitamin D levels and the possible outcomes of their deficiency during pregnancy has increased. However, there is no consensus on when to start vitamin D supplementation, its duration, dosage, and the optimum level during pregnancy. The toxicity of vitamin D is as important as its deficiency. From the history of a 5-day-old male baby who was investigated for hypercalcemia, it was learned that the mother took 300,000 IU vitamin D-five ampoules/oral at 30 weeks of gestation every other day. The infant was born prematurely, postpartum bradycardia required positive pressure ventilation, and his hypercalcemia lasted approximately 4 months despite treatment. Maternal excessive and inappropriate use of vitamin D can cause preterm labor and severe hypercalcemia, which is a life-threatening complication in the neonatal period. This case is presented to draw attention to the negative effects of maternal high-dose vitamin D during pregnancy.Keywords
This publication has 9 references indexed in Scilit:
- Understanding vitamin D metabolism in pregnancy: From physiology to pathophysiology and clinical outcomesMetabolism, 2018
- Transient neonatal hypercalcaemia secondary to excess maternal vitamin D intake: too much of a good thingBMJ Case Reports, 2017
- Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trialsFertility and Sterility, 2015
- Iatrogenic vitamin D toxicity in an infant – a case report and review of literatureThe Journal of Steroid Biochemistry and Molecular Biology, 2015
- Vitamin D and pregnancy outcomesCurrent Opinion in Obstetrics and Gynecology, 2014
- Effect of treatment of vitamin D deficiency and insufficiency during pregnancy on fetal growth indices and maternal weight gain: a randomized clinical trialEuropean Journal of Obstetrics & Gynecology and Reproductive Biology, 2013
- Vitamin D Deficiency in Turkish Mothers and Their Neonates and in Women of Reproductive AgeJournal of Clinical Research in Pediatric Endocrinology, 2009
- Effect of combined maternal and infant vitamin D supplementation on vitamin D status of exclusively breastfed infantsMaternal & Child Nutrition, 2008
- Vitamin D requirements during lactation: high-dose maternal supplementation as therapy to prevent hypovitaminosis D for both the mother and the nursing infantThe American Journal of Clinical Nutrition, 2004