Saturated Fatty Acid-Based In Situ Forming Matrices for Localized Antimicrobial Delivery
Open Access
- 25 August 2020
- journal article
- research article
- Published by MDPI AG in Pharmaceutics
- Vol. 12 (9), 808
- https://doi.org/10.3390/pharmaceutics12090808
Abstract
In recent years, the world has faced the issue of antibiotic resistance. Methicillin-resistant Staphylococcus aureus (MRSA) is a significant problem in various treatments and control of infections. Biocompatible materials with saturated fatty acids of different chain lengths (C8–C18) were studied as matrix formers of localized injectable vancomycin HCl (VCM)-loaded antisolvent-induced in situ forming matrices. The series of fatty acid-based in situ forming matrices showed a low viscosity (5.47–13.97 cPs) and pH value in the range of 5.16–6.78, with high injectability through a 27-G needle (1.55–3.12 N). The preparations exhibited low tolerance to high concentrations of KH2PO4 solution (1.88–5.42% v/v) and depicted an electrical potential change during phase transformation. Their phase transition and matrix formation at the microscopic and macroscopic levels depended on the chain length of fatty acids and solvent characteristics. The VCM release pattern depended on the nucleation/crystallization and solvent exchange behaviors of the delivery system. The 35% w/v of C12–C16 fatty acid-based in situ forming matrix prolonged the VCM release over seven days in which C12, C14, C16 –based formulation reached 56, 84, and 85% cumulative drug release at 7th day. The release data fitted well with Higuchi’s model. The developed formulations presented efficient antimicrobial activities against standard S. aureus, MRSA, Escherichia coli, and Candida albicans. Hence, VCM-loaded antisolvent-induced fatty acid-based in situ forming matrix is a potential local delivery system for the treatment of local Gram-positive infection sites, such as joints, eyes, dermis of surgery sites, etc., in the future.This publication has 89 references indexed in Scilit:
- Design of a long-term antipsychotic in situ forming implant and its release control method and mechanismInternational Journal of Pharmaceutics, 2012
- Surface and interfacial tensions of Hofmeister electrolytesFaraday Discussions, 2012
- Methicillin-Sensitive and Methicillin-Resistant Staphylococcus aureus: Preventing Surgical Site Infections Following Plastic SurgeryAesthetic Surgery Journal, 2009
- Fats and Fatty Acid Requirements for AdultsAnnals of Nutrition and Metabolism, 2009
- Methicillin-resistant Staphylococcus aureus (MRSA) among dental patients: a problem for infection control in dentistry?Clinical Oral Investigations, 2008
- Dimethyl sulfoxide toxicity kinetics in intact articular cartilageCell and Tissue Banking, 2006
- Correlation between Electric Potential and Interfacial Tension Oscillations in a Water−Oil−Water SystemThe Journal of Physical Chemistry B, 2004
- Drying of gelled sugar solutions—water diffusion behaviorChemical Engineering Journal, 2002
- Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matricesJournal of Pharmaceutical Sciences, 1963
- Studies of soap solutions. Part I. The fatty acid soaps and their hydrolysis in aqueous solutionsTransactions of the Faraday Society, 1949