Ductal Carcinoma in Situ: Quantitative Preoperative Breast MR Imaging Features Associated with Recurrence after Treatment
- 1 December 2017
- journal article
- Published by Radiological Society of North America (RSNA) in Radiology
- Vol. 285 (3), 788-797
- https://doi.org/10.1148/radiol.2017170587
Abstract
Quantitative MR imaging features of functional tumor volume, lesion signal enhancement ratio, and mean normal tissue background parenchymal enhancement show promise for use in the noninvasive assessment of ductal carcinoma in situ. PurposeTo investigate whether specific imaging features on breast magnetic resonance (MR) images are associated with ductal carcinoma in situ (DCIS) recurrence risk after definitive treatment.Materials and MethodsPatients with DCIS who underwent preoperative dynamic contrast material–enhanced (DCE) MR imaging between 2004 and 2014 with ipsilateral recurrence more than 6 months after definitive surgical treatment were retrospectively identified. For each patient, a control subject with DCIS that did not recur was identified and matched on the basis of clinical, histopathologic, and treatment features known to affect recurrence risk. On DCE MR images, lesion characteristics (longest diameter, functional tumor volume [FTV], peak percentage enhancement [PE], peak signal enhancement ratio [SER], and washout fraction) and normal tissue features (background parenchymal enhancement [BPE] volume, mean BPE) were quantitatively measured. MR imaging features were compared between patients and control subjects by usin...Funding Information
- Radiological Society of North America (2014–2016 Research Scholar Grant)
- National Institutes of Health (R01CA203883)
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