The work discusses the reign of George II, this period includes not only the history of Imereti, but also the history of Odishi, Guria, Samtskhe-Saatabago, and this significantly changes the many points of view we had in historiography until now.After reviewing the written sources, we found out that according to the reign of George II, the death of Bagrat III [1565 ], which is shared in our historiography by Iv. Javakhishvili is incorrect. Vakhushti’s date – 1548 is correct [with one or two years error -1549 or 1550]. According to our research, the first spouse of George II is Tamar, the daugheter of Shermazan Diasamidze [and not the second], accordingly his second spouse is Rusudan Sharvashidze, who is regarded by some researchers as his first wife. We were also able to find out that the unsuccessful marriage of George II to Tamar Diasamidze [1535] is the result of the hostile relationship between the authorities of Samtskhe-Saatabagago [Nav-Kvarkvare III, Qaikhosro II] and the authorities of the Kingdom of Imereti [Bagrat III, George II] in the 30s and 50s of the XVI century, when Shermazan Diasamidze commanded the Feudal Lords opposed to the Qaikhosro II Jakhel. The facts that Queen Tamar became a Nun (1561) and the heir of the throne, Mamia disappeared from the royal Palace are connected to the truce of George II and Qaikhosro II in 1562.A number of important facts that happened throughout western Georgia in the 16th century,have also been specified and explained including the tragic end of the family of George II.