The Combination of Turmeric (Curcuma domestica) Rhizome Extract and Collagen in A Serum Formulation as an Antioxidant
Borneo Journal of Pharmacy , Volume 4, pp 36-42; doi:10.33084/bjop.v4i1.1578
Abstract: Turmeric (Curcuma domestica) has nutritious compounds called curcuminoids, which can be used as antioxidants. As an antioxidant, C. domestica extract can be used to ward off free radicals that damage collagen and elastin, a protein that keeps skin moist. This study aimed to determine the antioxidant activity of serum combined with the addition of collagen using the DPPH method. The DPPH was made at a concentration of 80 μg/mL, and the absorption was read at a wavelength of 520 nm using a microplate rider. The study was conducted by making six formulations, namely F0, F1, F2, F3, F4, and F5 obtained the results of serum made from C. domestica extract that can inhibit free radicals and meet the physical evaluation test requirements of serum. Furthermore, the formula is made using only one active ingredient and only collagen to determine the antioxidant activity influenced by the extract or collagen. The results obtained indicate that collagen has a supporting role in adding antioxidant activity apart from the extract used. The highest % inhibition value at F5 with 90.526% can be said to ward off free radicals.
Keywords: Collagen / antioxidant activity / Free radicals / Serum / DPPH / Curcuma / turmeric / domestica / extract can be used
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