Executive Functioning in Schizophrenia
Open Access
- 1 January 2013
- journal article
- review article
- Published by Frontiers Media SA in American Journal of Translational Research
- Vol. 4, 35
- https://doi.org/10.3389/fpsyt.2013.00035
Abstract
The executive function (EF) is a set of abilities, which allows us to invoke voluntary control of our behavioral responses. These functions enable human beings to develop and carry out plans, make up analogies, obey social rules, solve problems, adapt to unexpected circumstances, do many tasks simultaneously and locate episodes in time and place. EF includes divided attention and sustained attention, working memory, set-shifting, flexibility, planning and the regulation of goal directed behavior and can be defined as a brain function underlying the human faculty to act or think not only in reaction to external events but also in relation with internal goals and states. EF is mostly associated with dorsolateral prefrontal cortex (PFC). Besides EF, PFC is involved in self-regulation of behavior, i.e. the ability to regulate behavior according to internal goals and constraints, particularly in less structured situations. Self-regulation of behavior is subtended by ventral medial /orbital PFC. Impairment of EF is one of the most commonly observed deficits in schizophrenia through the various disease stages. Impairment in tasks measuring conceptualization, planning, cognitive flexibility, verbal fluency, ability to solve complex problems and working memory occur in schizophrenia. Disorders detected by executive tests are consistent with evidence from functional neuroimaging, which have shown PFC dysfunction in patients while performing these kinds of tasks. Schizophrenics also exhibit deficit in odor identifying, decision-making and self-regulation of behavior suggesting dysfunction of the orbital PFC. However, impairment in executive tests is explained by dysfunction of prefronto-striato-thalamic, prefronto-parietal and prefronto-temporal neural networks mainly. Disorders in executive functions may be considered central facts with respect to schizophrenia and it has been suggested that negative symptoms may be explained by that executive dysfunction.Keywords
This publication has 100 references indexed in Scilit:
- The variable nature of cognitive control: a dual mechanisms frameworkTrends in Cognitive Sciences, 2012
- Schizophrenia as a disorder of disconnectivityArchiv Fur Psychiatrie Und Nervenkrankheiten, 2011
- The developmental course of executive functioning in schizophreniaInternational Journal of Developmental Neuroscience, 2011
- Cognitive Control Deficits in Schizophrenia: Mechanisms and MeaningNeuropsychopharmacology, 2010
- Executive Function, Neural Circuitry, and Genetic Mechanisms in SchizophreniaNeuropsychopharmacology, 2009
- Is the rostro-caudal axis of the frontal lobe hierarchical?Nature Reviews Neuroscience, 2009
- Meta-analysis of 41 Functional Neuroimaging Studies of Executive Function in SchizophreniaArchives of General Psychiatry, 2009
- Hierarchical cognitive control deficits following damage to the human frontal lobeNature Neuroscience, 2009
- Dysconnection in Schizophrenia: From Abnormal Synaptic Plasticity to Failures of Self-monitoringSchizophrenia Bulletin, 2009
- Common Neural Circuitry Supporting Volitional Saccades and Its Disruption in Schizophrenia Patients and RelativesBiological Psychiatry, 2008