Pharmacological evaluation of ONNO donor quadridentate Schiff bases
- 31 March 2017
- journal article
- Published by European Journal of Chemistry in European Journal of Chemistry
- Vol. 8 (1), 46-51
- https://doi.org/10.5155/eurjchem.8.1.46-51.1535
Abstract
Four ONNO donor Schiff bases 2-((E)-(2-((E)-2-hydroxybenzylideneamino)ethylimino) methyl)phenol (H2L1), 2-((E)-(2-((E)-2-hydroxybenzylideneamino)propylimino)methyl) phenol (H2L2), 2-((E)-1-(2-((E)-1-(2-hydroxyphenyl) ethylideneamino)ethylimino)ethyl) phenol (H2L3) and 2-((E)-1-(2-((E)-1-(2-hydroxyphenyl)ethylideneamino)propylimino) ethyl)phenol (H2L4) were synthesized by the reactions of ethylene/propylene diamines with 2-hydroxy benzaldehyde/2-hydroxy acetophenone. The new compounds were characterized by FT-IR and NMR (1H and 13C) spectroscopic techniques accompanied by elemental, GC/MS and single crystal X-ray diffraction analyses. These compounds were screened for various biological studies i.e. brine shrimp cytotoxic, antitumor and antibacterial activities The compound H2L3 showed highest cytotoxic and antitumor activities with lowest LD50 (14.27) and IC50 values (18.90). All the compounds were highly active in protecting DNA against hydroxyl free radicals. Antibacterial studies had shown that these were inactive against Gram positive bacteria (Staphylococcus aureus and Micrococcus luteus) while active against Gram negative bacteria (Enterobacter aerogenes, Bordetella bronchiseptica and Salmonella typhi) showing variable antibacterial activity.Keywords
This publication has 10 references indexed in Scilit:
- Synthesis, characterization, biological and electrochemical evaluation of novel ether based ON donor bidentate Schiff basesJournal of Molecular Structure, 2016
- Synthesis and characterization of redox non-innocent cobalt(III) complexes of a O,N,O donor ligand: Radical generation, semi-conductivity, antibacterial and anticancer activitiesInorganica Chimica Acta, 2015
- Synthesis, characterization and biological relevance of some metal (II) complexes with oxygen, nitrogen and oxygen (ONO) donor Schiff base ligand derived from thiazole and 2-hydroxy-1-naphthaldehydeJournal of Molecular Structure, 2015
- Antipathogenic effects of structurally-related Schiff base derivatives: Structure–activity relationshipArabian Journal of Chemistry, 2013
- Antimicrobial activity of Schiff bases of coumarin-incorporated 1,3,4-oxadiazole derivatives: an in vitro evaluationMedicinal Chemistry Research, 2013
- Synthesis, anti-bacterial and anti-fungal activities of some novel Schiff bases containing 2,4-disubstituted thiazole ringEuropean Journal of Medicinal Chemistry, 2010
- A short history of SHELXActa Crystallographica Section A Foundations of Crystallography, 2007
- Combinatorial Synthesis, Lead Identification, and Antitumor Study of a Chalcone‐Based Positional‐Scanning LibraryChemistry & Biodiversity, 2007
- The Cambridge Structural Database: a quarter of a million crystal structures and risingActa crystallographica Section B, Structural science, crystal engineering and materials, 2002
- Investigation on some Schiff bases as HCl corrosioninhibitors for copperCorrosion Science, 1999