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Dose-dependent effects of simvastatin, atorvastatin and rosuvastatin on apoptosis and inflammation pathways on cancerous lung cells

Nursel Dikmen, Hüseyin Özkan, Funda Çimen, Baran Çamdeviren, Emrah Ay, Pınar Ambarcioğlu, Nizami Duran, Akın YAKIN

Abstract: The aim of study was to investigate the proliferative and inflammatory effects of atorvastatin, rosuvastatin, and simvastatin in lung cancer. The effects of statins were investigated in Vero, BEAS-2B, and A549 cell lines. In addition to expressions of BAX, BCL-2, TNFα, IL-10, IL-6, protein levels of TNFα, IL-10, IL-6 were determined. Cell viability and MDA were also measured. While the cell numbers in groups with low doses of statins were found to be approximately 1x106/mL, proliferation was inhibited at higher rates containing high doses. Simvastatin, rosuvastatin and high dose atorvastatin upregulated the BAX, while high dose of atorvastatin and both doses of rosuvastatin caused downregulation in BCL-2. All statin groups had higher MDA. Simvastatin and high dose rosuvastatin upregulated TNFα. Low dose simvastatin and atorvastatin and high dose atorvastatin and rosuvastatin upregulated IL-10. IL-6 were upregulated with low dose of rosuvastatin. TNFα was higher in simvastatin and rosuvastatin groups. IL-10 were highest in rosuvastatin groups. Atorvastatin groups had lower IL-6. Although cell numbers have reduced by all statins, rosuvastatin are more effective on studied genes. Findings may give important insights about drugs and target receptors to be used with and without statins in cancer treatment.
Keywords: simvastatin / apoptosis / viability / atorvastatin and rosuvastatin / lung / protein / treatment / TNFα

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