Macrocycle Dynamics in a Branched [8]Catenane Controlled by Three Different Stimuli in Three Different Regions
- 22 October 2021
- journal article
- research article
- Published by Wiley in Angewandte Chemie
- Vol. 61 (1), e202110200
- https://doi.org/10.1002/anie.202110200
Abstract
A branched [8]catenane from an efficient one-pot synthesis (72% HPLC yield, 59% isolated yield) featuring the simultaneous use of three kinds of templates and cucurbit[6]uril-mediated azide-alkyne cycloaddition (CBAAC) for ring-closing is reported. Design and assembly of the [8]catenane precursors are unexpectedly complex that can involve cooperating, competing and non-influencing interactions. Due to the branched structure, dynamics of the [8]catenane can be modulated in different extent by rigidifying/loosening the mechanical bonds at different regions by using solvent polarity, acid-base and metal ions as the stimuli. This work not only highlights the importance of understanding the delicate interplay of the weak and non-obvious supramolecular interactions in the synthesis of high-order [n]catenane, but also demonstrates a complex control of dynamics and flexibility for exploiting [n]catenanes applications.Funding Information
- Croucher Foundation
- CAS-Croucher Funding Scheme for Joint Laboratories
- Research Grants Council, University Grants Committee (HKU 27300014)
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