Microwave-Assisted and Solvent-Free Synthesis of Quinoline Derivatives and Their Fluorescence Properties

Abstract

A protocol for the microwave-assisted Friedlander synthesis of quinoline derivatives under solvent-free conditions has been developed. According to this modified method, quinoline derivatives were synthesized by condensation of 2-aminobenzophenone with the corresponding carbonyl compounds in the presence of phosphomolybdic acid for 8 min in a 320 W microwave with yields ranging from 61% to 90%. The fluorescence properties of the synthesized compounds were studied, and all compounds showed good fluorescence properties. The substituted groups and the concentrations of quinolines and solvents had significant effects on the compounds' fluorescence properties. This method provides a convenient way to obtain quinolines, and is beneficial to the application of these compounds.