Honey contains many nutrients including vitamins A, C, E, B12, β-carotene and phalvonoid which can increase hemoglobin and suppress oxidative stress. This study aims to determine the effect of honey administration on Hemoglobin Levels and 8-hydroxy-2-Deoxyguanosin (8-Ohdg) levels in pregnant women with anemia. This study uses a type of Quasi Experiment research with pretest-posttest research design, Sample in a study of 30 pregnant women divided into 2 groups, mothers who received Fe (Control Group) and Honey + Fe (Intervention Group) Implementation carried out for 60 days. Then blood and urine are taken to examine hemoglobin levels and 8-Ohdg levels. Data were analyzed using Paired Sample T Test and Independent T Test. The results showed an increase in hemoglobin levels in the intervention group Honey + Fe by (2.80 ± 0.26gr / dl) while the Fe control group was (0.80 ± 0.13gr / dl) with a value of p = 0,001 <0, 05. The 8-Ohdg level in the intervention group Honey + Fe was (-4.23 ± 1.32 nmol / ml p = 0.031 0 , 05). Based on the Independent T Test on hemoglobin levels, the values of p = 0,001 <0,005 and 8-Ohdg values obtained p value = 0,002 <0,05. Thus the group given Honey + Fe is more effective in increasing hemoglobin levels and decreasing levels of 8-Ohdg in anemic pregnant women.