Personalized risk prediction of postoperative cognitive impairment – rationale for the EU-funded BioCog project
- 25 October 2017
- journal article
- research article
- Published by Cambridge University Press (CUP) in European Psychiatry
- Vol. 50, 34-39
- https://doi.org/10.1016/j.eurpsy.2017.10.004
Abstract
Postoperative cognitive impairment is among the most common medical complications associated with surgical interventions – particularly in elderly patients. In our aging society, it is an urgent medical need to determine preoperative individual risk prediction to allow more accurate cost–benefit decisions prior to elective surgeries. So far, risk prediction is mainly based on clinical parameters. However, these parameters only give a rough estimate of the individual risk. At present, there are no molecular or neuroimaging biomarkers available to improve risk prediction and little is known about the etiology and pathophysiology of this clinical condition. In this short review, we summarize the current state of knowledge and briefly present the recently started BioCog project (Biomarker Development for Postoperative Cognitive Impairment in the Elderly), which is funded by the European Union. It is the goal of this research and development (R&D) project, which involves academic and industry partners throughout Europe, to deliver a multivariate algorithm based on clinical assessments as well as molecular and neuroimaging biomarkers to overcome the currently unsatisfying situation.Keywords
This publication has 30 references indexed in Scilit:
- Association of pre‐operative brain pathology with post‐operative delirium in a cohort of non‐small cell lung cancer patients undergoing surgical resectionPsycho‐Oncology, 2013
- Cognitive Trajectories after Postoperative DeliriumThe New England Journal of Medicine, 2012
- The association between brain volumes, delirium duration, and cognitive outcomes in intensive care unit survivorsCritical Care Medicine, 2012
- Prior Pathology in the Basal Forebrain Cholinergic System Predisposes to Inflammation-Induced Working Memory Deficits: Reconciling Inflammatory and Cholinergic Hypotheses of DeliriumJournal of Neuroscience, 2012
- Surgery and Brain Atrophy in Cognitively Normal Elderly Subjects and Subjects Diagnosed with Mild Cognitive ImpairmentAnesthesiology, 2012
- Resolving postoperative neuroinflammation and cognitive declineAnnals of Neurology, 2011
- Postoperative DeliriumAnesthesia & Analgesia, 2011
- Postoperative delirium and cognitive dysfunctionBritish Journal of Anaesthesia, 2009
- Delirium is associated with early postoperative cognitive dysfunctionAnaesthesia, 2008
- The Metabolic Syndrome, Inflammation, and Risk of Cognitive DeclineJAMA, 2004