Khulna railway station is one of the oldest establishments which is situated almost at the heart of Khulna city center, known as the Central Business District (CBD) of Khulna city. To support the growing demand for transport services in the CBD area, the existing three major transport modes (railway, waterway, and roadway) of the railway station area are fully functioning. Though they are situated in the same area for serving the same purposes but work separately. This separate route plan of the three transport modes demands more support services which cause traffic congestion and space scarcity to accommodate heavy weight vehicles like cargo trucks and lorry. The rapid growth of the economy and population of the city demand an upgraded transportation infrastructure. This paper aims to explore the context-specific challenges for planning transportation infrastructure in the CBD and its settlement area. A field survey of the study area, face-to-face interviews of different stakeholders, and questionnaire survey were conducted to gather necessary primary data. Detailed Area plan of Khulna Development Authority (KDA), Khulna City Master plans, newspaper cuttings, journal and conference papers, etc. are analyzed. This paper provides an overview of hazardous conditions of the study area caused by the existing public and freight transportation. Respecting the existing problems and limitations, an integrated transport infrastructure planning guideline has been provided to meet the future transport challenges in the densely populated urban CBD area.