Combinations of modifiable lifestyle behaviours in relation to colorectal cancer risk in Alberta’s Tomorrow Project
Open Access
- 25 November 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Scientific Reports
- Vol. 10 (1), 1-11
- https://doi.org/10.1038/s41598-020-76294-w
Abstract
The objective of this study was to identify distinct clusters of individuals that exhibit unique patterns of modifiable lifestyle-related behaviours and to determine how these patterns are associated with the risk of developing colorectal cancer (CRC). The study consisted of 26,460 participants and 267 CRC cases from Alberta’s Tomorrow Project. Exploratory latent class analysis of risk behaviours (obesity, physical inactivity, meat consumption, smoking, alcohol consumption, and fruit and vegetable consumption) and Cox proportional hazard models were utilized. Seven unique behavioural groups were identified, where the risk of CRC was 2.34 to 2.87 times greater for high risk groups compared to the low risk group. Sex-specific models identified higher risk groups among men (Hazard Ratios [HRs]: 3.15 to 3.89) than among women (HRs: 1.99 to 2.19). Targeting groups defined by clustering of behaviours could potentially lead to more effective prevention of CRC on a population level.This publication has 25 references indexed in Scilit:
- Age and gender as moderators of the relationship between physical activity and alcohol useAddictive Behaviors, 2011
- Does Individual Risk Moderate the Effect of Contextual-Level Protective Factors? A Latent Class Analysis of Substance UseJournal of Prevention & Intervention in the Community, 2010
- The Canadian Partnership for Tomorrow Project: building a pan-Canadian research platform for disease preventionCMAJ : Canadian Medical Association Journal, 2010
- Annual report to the nation on the status of cancer, 1975‐2006, featuring colorectal cancer trends and impact of interventions (risk factors, screening, and treatment) to reduce future ratesCancer, 2009
- Colorectal Cancer Epidemiology: Incidence, Mortality, Survival, and Risk FactorsClinics in Colon and Rectal Surgery, 2009
- Latent Class Analysis of Lifestyle Characteristics and Health Risk Behaviors among College YouthPrevention Science, 2009
- Characteristics of Physically Active Smokers and Implications for Harm ReductionAmerican Journal of Public Health, 2008
- The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) StatementEpidemiology, 2007
- Association between smoking and alcohol use in the general population: stable and unstable odds ratios across two years in two different countriesAlcohol and Alcoholism, 2007
- Checking the Cox model with cumulative sums of martingale-based residualsBiometrika, 1993