New Search

Export article

Metal-Free Selective Modification of Secondary Amides: Application in Late-Stage Diversification of Peptides

Victor Adebomi, Mahesh Sriram, Xavier Streety, Monika Raj
Published: 12 July 2021

Abstract: Here we solve a long-standing challenge of the site-selective modification of secondary amides and present a simple two-step, metal-free approach to selectively modify a particular secondary amide in molecules containing multiple primary and secondary amides. Density functional theory (DFT) provides insight into the activation of C–N bonds. This study encompasses distinct chemical advances for late-stage modification of peptides thus harnessing the amides for the incorporation of various functional groups into natural and synthetic molecules.
Keywords: functional / Late Stage / secondary amides / metal free / selective modification

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

Share this article

Click here to see the statistics on "Organic Letters" .
References (27)
    Back to Top Top