Inflammatory cytokines in and cognitive function of adolescents with first-episode schizophrenia, bipolar disorder, or major depressive disorder
- 19 October 2021
- journal article
- research article
- Published by Cambridge University Press (CUP) in CNS Spectrums
- Vol. 28 (1), 70-77
- https://doi.org/10.1017/s1092852921000857
Abstract
Background Few studies have explored the complex relationship of pro- and anti-inflammatory cytokines with cognitive function in adolescents with first-episode schizophrenia, bipolar disorder, or major depressive disorder. Methods In total, 26, 35, and 29 adolescents with first-episode schizophrenia, bipolar disorder, and major depressive disorder, respectively, and 22 age- and sex-matched controls were included in the current study. Cytokines, namely interleukin (IL)-2, IL-6, tumor necrosis factor (TNF)-alpha, and C-reactive protein (CRP), were assessed. The Wisconsin Card Sorting Test (WCST) and the working memory task were administered to assess cognitive function. Results Using generalized linear models with adjustment for demographic data and clinical symptoms, patients with bipolar disorder were found to exhibit the highest levels of CRP (P = .023), IL-6 (P = .022), and TNF-alpha (P = .011), and had the lowest IL-2 levels (P = .034) among the four groups. According to the results of the WCST and working memory task, adolescents with schizophrenia exhibited the lowest performance in cognitive function. In addition, among the assessed cytokines, only CRP levels (P = .027) were negatively associated with WCST scores. Discussion Dysregulated pro- and anti-inflammatory cytokines and impaired cognitive functioning were observed in first-episode adolescent-onset schizophrenia, bipolar disorder, and major depressive disorder. The altered cytokine profiles may play important roles in the pathophysiology of schizophrenia, bipolar disorder, and major depressive disorder.Keywords
This publication has 39 references indexed in Scilit:
- The association between depressive symptoms, cognitive function, and inflammation in major depressionBrain, Behavior, and Immunity, 2014
- Systematic review and collaborative recalculation of 133 693 incident cases of schizophreniaPsychological Medicine, 2012
- Neuropsychological evidence for abnormal neurodevelopment associated with early-onset psychosesPsychological Medicine, 2012
- A comparison of neuropsychological dysfunction in first-episode psychosis patients with unipolar depression, bipolar disorder, and schizophreniaSchizophrenia Research, 2009
- Patterns of neurocognitive impairment in first-episode bipolar disorder and schizophreniaThe British Journal of Psychiatry, 2009
- Neuropsychology of First-Episode Schizophrenia: Initial Characterization and Clinical CorrelatesAmerican Journal of Psychiatry, 2000
- Major depressive disorder in older adolescents: Prevalence, risk factors, and clinical implicationsClinical Psychology Review, 1998
- Negative v Positive SchizophreniaArchives of General Psychiatry, 1982
- A Rating Scale for Mania: Reliability, Validity and SensitivityThe British Journal of Psychiatry, 1978
- A RATING SCALE FOR DEPRESSIONJournal of Neurology, Neurosurgery & Psychiatry, 1960