This study is a part of a wider study. The purpose of this study is to look at the differences between the level of moral distress of medical-surgical nurses in Hail Saudi Arabia and their demographics. This study used a descriptive-comparative research design using the Moral Distress Questionnaire through an online survey. There are 274 respondents in this study. The statistical test used is frequency, percentage, mean, standard deviation, t-test, and one-way ANOVA. Results include regarding sex, t-test scored t (272) =-4.48; p=<0.001. Concerning civil status, t-test scored t (272) =0.35; p=0.72. Regarding age, one-way ANOVA score F (3,270) =1.78; p= 0.15. About the place of work, t-test scored t (272) =3.73; p=<0.001. Regarding years of experience one-way ANOVA scored F (2,269) =2.61; p= 0.04. Finally, on religious affiliation one-way ANOVA scored F (2,271) =2.32; p=0.10. The researchers conclude that the level of their moral distress varies with their sex, place of work, and years of experience. However, moral distress does not change with their civil status, age, and religious affiliation.