Harnessing the power of yeast to elucidate the role of sphingolipids in metabolic and signaling processes pertinent to psychiatric disorders
- 1 October 2014
- journal article
- Published by Taylor & Francis Ltd in Clinical Lipidology
- Vol. 9 (5), 533-551
- https://doi.org/10.2217/clp.14.47
Abstract
The development of therapies for neuropsychiatric disorders is hampered by the lack of understanding of the mechanisms underlying their pathologies. While aberrant sphingolipid metabolism is associated with psychiatric illness, the role of sphingolipids in these disorders is not understood. The genetically tractable yeast model can be exploited in order to elucidate the cellular consequences of sphingolipid perturbation. Hypotheses generated from studies in yeast and tested in mammalian cells may contribute to our understanding of the role of sphingolipids in psychiatric disorders and to the development of new treatments. Here, we compare sphingolipid metabolism in yeast and mammalian cells, discuss studies implicating sphingolipids in psychiatric disorders and propose approaches that utilize yeast in order to elucidate sphingolipid function and identify drugs that target sphingolipid synthesis.Keywords
This publication has 156 references indexed in Scilit:
- Ceramide function in the brain: when a slight tilt is enoughCellular and Molecular Life Sciences, 2012
- Sphingolipid and Glycosphingolipid Metabolic Pathways in the Era of SphingolipidomicsChemical Reviews, 2011
- Involvement of murine β-1,4-galactosyltransferase V in lactosylceramide biosynthesisGlycoconjugate Journal, 2010
- Mammalian ceramide synthasesIUBMB Life, 2010
- Sphingosine Facilitates SNARE Complex Assembly and Activates Synaptic Vesicle ExocytosisNeuron, 2009
- Neurogenesis-Dependent and -Independent Effects of Fluoxetine in an Animal Model of Anxiety/DepressionNeuron, 2009
- Evidence for disruption of sphingolipid metabolism in schizophreniaJournal of Neuroscience Research, 2008
- Quantitative modeling of selective lysosomal targeting for drug designEuropean Biophysics Journal, 2008
- Yeast sphingolipids: Recent developments in understanding biosynthesis, regulation, and functionBiochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2007
- Lithium blocks the PKB and GSK3 dephosphorylation induced by ceramide through protein phosphatase-2ACellular Signalling, 2002