Abstract: Introduction: Nephrotoxicity is one of the most frequent kidney problems and happens when the body becomes exposed to medicine or toxin. Because renal tubular cells have metabolic activities, nephrotoxin can produce toxic components and cause damage. Paracetamol drug is safe when taken in therapeutic doses as an antipyretic and analgesic agent but its excessive doses may result in life-threatening renal impairment due to the generation of reactive-toxic metabolites. Scientific efforts are concentrated on discovering preventative or therapeutic medications to shield against the toxicity brought on by paracetamol due to nephrotoxicity. Silymarin, a medicine, is extracted from polyphenolic compounds found in the milk thistle plant. This plant has antioxidant, anti-inflammatory, anti-cancerous, and other properties and is the most commonly used drug for hepatic illnesses. Also, it has renal-protecting effects. Objective: This review research highlights the nephroprotective of silymarin against paracetamol-induced renal damage.