Functionalization of Metal and Carbon Nanoparticles with Potential in Cancer Theranostics
Open Access
- 21 May 2021
- Vol. 26 (11), 3085
- https://doi.org/10.3390/molecules26113085
Abstract
Cancer theranostics is a new concept of medical approach that attempts to combine in a unique nanoplatform diagnosis, monitoring and therapy so as to provide eradication of a solid tumor in a non-invasive fashion. There are many available solutions to tackle cancer using theranostic agents such as photothermal therapy (PTT) and photodynamic therapy (PDT) under the guidance of imaging techniques (e.g., magnetic resonance—MRI, photoacoustic—PA or computed tomography—CT imaging). Additionally, there are several potential theranostic nanoplatforms able to combine diagnosis and therapy at once, such as gold nanoparticles (GNPs), graphene oxide (GO), superparamagnetic iron oxide nanoparticles (SPIONs) and carbon nanodots (CDs). Currently, surface functionalization of these nanoplatforms is an extremely useful protocol for effectively tuning their structures, interface features and physicochemical properties. This approach is much more reliable and amenable to fine adjustment, reaching both physicochemical and regulatory requirements as a function of the specific field of application. Here, we summarize and compare the most promising metal- and carbon-based theranostic tools reported as potential candidates in precision cancer theranostics. We focused our review on the latest developments in surface functionalization strategies for these nanosystems, or hybrid nanocomposites consisting of their combination, and discuss their main characteristics and potential applications in precision cancer medicine.Keywords
This publication has 249 references indexed in Scilit:
- A nanoscale graphene oxide–peptide biosensor for real-time specific biomarker detection on the cell surfaceChemical Communications, 2012
- In Vivo Targeting and Imaging of Tumor Vasculature with Radiolabeled, Antibody-Conjugated NanographeneACS Nano, 2012
- Multistage Nanovectors: From Concept to Novel Imaging Contrast Agents and TherapeuticsAccounts of Chemical Research, 2011
- The Enzymatic Oxidation of Graphene OxideACS Nano, 2011
- Surface functionalization of magnetic iron oxide nanoparticles for MRI applications – effect of anchoring group and ligand exchange protocolContrast Media & Molecular Imaging, 2010
- Efficacy and safety of intratumoral thermotherapy using magnetic iron-oxide nanoparticles combined with external beam radiotherapy on patients with recurrent glioblastoma multiformeJournal of Neuro-Oncology, 2010
- Multiwavelength Photoacoustic Imaging and Plasmon Resonance Coupling of Gold Nanoparticles for Selective Detection of CancerNano Letters, 2009
- A novel strategy for surface modification of superparamagnetic iron oxide nanoparticles for lung cancer imagingJournal of Materials Chemistry, 2009
- Particle Size, Surface Coating, and PEGylation Influence the Biodistribution of Quantum Dots in Living MiceSmall, 2009
- PEGylated Nanographene Oxide for Delivery of Water-Insoluble Cancer DrugsJournal of the American Chemical Society, 2008