Selecting Patients With Locally Advanced Rectal Cancer for Neoadjuvant Treatment Strategies
- 1 July 2013
- journal article
- research article
- Published by Oxford University Press (OUP) in The Oncologist
- Vol. 18 (7), 833-842
- https://doi.org/10.1634/theoncologist.2013-0022
Abstract
Rectal cancer remains a significant problem worldwide. Outcomes vary significantly according to the stage of disease and prognostic factors, including the distance of the tumor from the circumferential resection margin. Accurate staging, including high-resolution magnetic resonance imaging, allows stratification of patients into low-, moderate-, and high-risk disease; this information can be used to inform multidisciplinary team decisions regarding the role of neoadjuvant therapy. Both neoadjuvant short-course radiotherapy and long-course chemoradiation reduce the risk of local recurrence compared with surgery alone, but they have little impact on survival. Although there remains a need to reduce overtreatment of those patients at moderate risk, evaluation of intensified regimens for those with high-risk disease is still required to reduce distant failure rates and improve survival in these patients with an otherwise poor prognosis.Keywords
Funding Information
- National Institute for Health Research Biomedical Research Centre
- Peter Stebbings Memorial Charity
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