Sea cucumber sulfated polysaccharides and Lactobacillus gasseri synergistically ameliorate the overweight induced by altered gut microbiota in mice
- 27 March 2023
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Food & Function
- Vol. 14 (9), 4106-4116
- https://doi.org/10.1039/d2fo03933h
Abstract
Sulfated polysaccharides from sea cucumber Stichopus japonicus (SCSPsj) have been found to modulate the gut microbiota by promoting the growth of probiotics. However, the effects of the combination of SCSPsj and probiotics are still less known. Thus, the present study aimed to investigate the effects of SCSPsj and Lactobacillus gasseri on gut microbiota-altered mice through gut microbiota and metabolomics analysis. In the present study, supplementation with SCSPsj, L. gasseri or the combination of SCSPsj and L. gasseri could effectively ameliorate the body weight gain and fat accumulation in gut microbiota-altered mice treated with low-dose penicillin. The better effect of the combination of SCSPsj and L. gasseri is attributed to the synergistic effect of SCSPsj and L. gasseri. 16S rRNA sequencing revealed that the combination of SCSPsj and L. gasseri can synergistically improve gut microbiota dysbiosis by increasing Lactobacillus and reducing Coriobacteriaceae_UCG-002. Furthermore, metabolomics results revealed that the combination of SCSPsj and L. gasseri can alleviate metabolic disorders by reducing the levels of lipid and lipid-like molecules in the serum samples, such as trans-vaccenic acid and 3β-hydroxy-5-cholestene. Our findings have proved that the combination of SCSPsj and L. gasseri can benefit host health attributed to the synergistic effect, which is conducive to further application in functional food.Funding Information
- National Natural Science Foundation of China (31972084)
This publication has 52 references indexed in Scilit:
- Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in MiceScience, 2013
- Serum Lipid Profiles and Cancer Risk in the Context of Obesity: Four Meta-AnalysesJournal of Cancer Epidemiology, 2013
- Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesityNature, 2012
- Antibiotic Treatment Alters the Colonic Mucus Layer and Predisposes the Host to Exacerbated Citrobacter rodentium -Induced ColitisInfection and Immunity, 2011
- Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41Proceedings of the National Academy of Sciences of the United States of America, 2008
- An obesity-associated gut microbiome with increased capacity for energy harvestNature, 2006
- ObesityThe Lancet, 2005
- SerumTrans-Fatty Acids Are Associated with Risk of Prostate Cancer in β-Carotene and Retinol Efficacy TrialCancer Epidemiology, Biomarkers & Prevention, 2005
- Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. AdultsThe New England Journal of Medicine, 2003
- Survival ofLactobacillus species (strain GG) in human gastrointestinal tractDigestive Diseases and Sciences, 1992