Effect of nonsurgical periodontal therapy and smoking status on hematological variables related to anemia of chronic disease in chronic periodontitis patient: a case-control study
Open Access
- 31 July 2022
- journal article
- research article
- Published by Yeungnam University College of Medicine in Journal of Yeungnam Medical Science
- Vol. 39 (3), 244-249
- https://doi.org/10.12701/jyms.2022.00045
Abstract
Background: Chronic infectious, inflammatory, or neoplastic disorders are associated with anemia of chronic disease. Chronic inflammatory diseases such as periodontitis may contribute to masked anemia, especially in smokers. This study was aimed at verifying and comparing the efficacy of nonsurgical periodontal therapy (NSPT) for improving anemia among chronic periodontitis patients with and without the habit of smoking. Methods: Thirty systemically healthy individuals with chronic periodontitis were divided into two groups of 15 each, smokers (group A) and nonsmokers (group B). The groups were compared based on hematological parameters such as serum erythropoietin (SE) and serum ferritin (SF) levels at baseline and 3 months after NSPT for anemia evaluation. Results: The baseline SE levels in groups A and B were 11.84 and 15.19 mIU/mL (p=0.031), respectively; the corresponding levels at 3 months after NSPT were 13.00 and 17.74 mIU/mL (p=0.022). The baseline SF levels in groups A and B were 95.49 and 44.86 ng/mL (p=0.018), respectively; the corresponding levels at 3 months after NSPT were 77.06 and 39.05 ng/mL (p= 0.009). Group B showed a significant increase and decrease in the SE and SF levels, respectively, at 3 months after NSPT (p= 0.035 and p= 0.039, respectively), whereas group A showed insignificant changes (p= 0.253 and p=0.618, respectively). Conclusion: NSPT led to an improvement in anemia among chronic periodontitis patients. However, the improvement is less in smokers compared to that in nonsmokers. Furthermore, SF and SE levels might serve as effective biomarkers for assessing anemia in smokers and nonsmokers with chronic periodontitis.Keywords
This publication has 24 references indexed in Scilit:
- Janus Kinase V617F mutation in cigarette smokersAmerican Journal of Hematology, 2011
- Generalized, severe, chronic periodontitis is associated with anemia of chronic disease: a pilot study in urban, Indian malesJournal of Investigative and Clinical Dentistry, 2010
- Increased Serum Iron Levels and Infectious Complications after Liver TransplantationClinical Infectious Diseases, 2010
- The Influence of Tobacco Smoking on the Onset of Periodontitis in Young PersonsTobacco Induced Diseases, 2004
- Pathogenesis and treatment of anaemia of chronic diseaseBlood Reviews, 2002
- Effect of Periodontitis and Smoking on Blood Leukocytes and Acute‐Phase ProteinsThe Journal of Periodontology, 1999
- Proinflammatory Cytokines Lowering Erythropoietin ProductionJournal of Interferon & Cytokine Research, 1998
- Clinical Applications of Measurement of Serum Immunoreactive Levels of ErythropoietinAnnals of the New York Academy of Sciences, 1985
- SERUM C‐REACTIVE PROTEIN LEVELS IN DISEASE*Annals of the New York Academy of Sciences, 1982
- Diurnal Levels of Immunoreactive Erythropoietin in Normal Subjects and Subjects with Chronic Lung DiseaseBritish Journal of Haematology, 1981