Toxicity of metallic nanoparticles in the central nervous system
Open Access
- 6 November 2019
- journal article
- review article
- Published by Walter de Gruyter GmbH in Nanotechnology Reviews
- Vol. 8 (1), 175-200
- https://doi.org/10.1515/ntrev-2019-0017
Abstract
Metallic nanoparticles due to their small size and unique physico-chemical characteristics have found excellent applications in various branches of industry and medicine. Therefore, for many years a growing interest has been observed among the scientific community in the improvement of our understanding of the impact of nanoparticles on the living organisms, especially on humans. Considering the delicate structure of the central nervous systemit is one of the organs most vulnerable to the adverse effects of metallic nanoparticles. For that reason, it is important to identify the modes of exposure and understand the mechanisms of the effect of nanoparticles on neuronal tissue. In this review, an attempt is undertaken to present current knowledge about metallic nanoparticles neurotoxicity based on the selected scientific publications. The route of entry of nanoparticles is described, as well as their distribution, penetration through the cell membrane and the blood-brain barrier. In addition, a study on the neurotoxicity in vitro and in vivo is presented, as well as some of the mechanisms that may be responsible for the negative effects of metallic nanoparticles on the central nervous system. Graphical This review summarizes the current knowledge on the toxicity of metallic NPs in the brain and central nervous system of the higher vertebrates.Keywords
This publication has 151 references indexed in Scilit:
- Increased nanoparticle‐loaded exogenous macrophage migration into the brain following PDT‐induced blood–brain barrier disruptionLasers in Surgery and Medicine, 2013
- Silver nanoparticles (AgNPs) cause degeneration of cytoskeleton and disrupt synaptic machinery of cultured cortical neuronsMolecular Brain, 2013
- Identification of potential biomarkers of gold nanoparticle toxicity in rat brainsJournal of Neuroinflammation, 2012
- Effects of nanoparticle zinc oxide on spatial cognition and synaptic plasticity in mice with depressive-like behaviorsJournal of Biomedical Science, 2012
- Nano-zinc oxide damages spatial cognition capability via over-enhanced long-term potentiation in hippocamus of Wistar ratsInternational Journal of Nanomedicine, 2011
- Size and surface charge of gold nanoparticles determine absorption across intestinal barriers and accumulation in secondary target organs after oral administrationNanotoxicology, 2011
- Distribution of silver in rats following 28 days of repeated oral exposure to silver nanoparticles or silver acetateParticle and Fibre Toxicology, 2011
- A review of nanoparticle functionality and toxicity on the central nervous systemJournal of The Royal Society Interface, 2010
- Toxicity of Tungsten Carbide and Cobalt-Doped Tungsten Carbide Nanoparticles in Mammalian Cells in VitroEnvironmental Health Perspectives, 2009
- Manufactured Aluminum Oxide Nanoparticles Decrease Expression of Tight Junction Proteins in Brain VasculatureJournal of Neuroimmune Pharmacology, 2008