Dietary Platycodon grandiflorus Attenuates Hepatic Insulin Resistance and Oxidative Stress in High-Fat-Diet Induced Non-Alcoholic Fatty Liver Disease
Open Access
- 14 February 2020
- Vol. 12 (2), 480
- https://doi.org/10.3390/nu12020480
Abstract
The root of Platycodon grandiflorus (PG), with hepatoprotective and anti-oxidation effects, has a long history of being used as food and herbal medicine in Asia. However, the mechanism of PG against non-alcoholic fatty liver disease (NAFLD) is still not clear. The aim of this study was to investigate the mechanism of PG suppressing the development of NAFLD induced by a high-fat diet (HFD) in mice. Male C57BL/6J mice were fed with either a standard chow diet or a HFD, either supplemented with or without PG, for 16 weeks. Serum lipids, liver steatosis, oxidative stress and insulin sensitivity were determined. Expressions or activities of hepatic enzymes in the related pathways were analyzed to investigate the mechanisms. PG significantly reduced HFD-induced hepatic injury and hyperlipidemia, as well as hepatic steatosis via regulating phosphorylation of acetyl-CoA carboxylase (p-ACC) and expression of fatty acid synthase (FAS). In addition, PG ameliorated oxidative stress by restoring glutathione (GSH) content and antioxidant activities, and improved insulin sensitivity by regulating the PI3K/Akt/GSK3β signaling pathway. Our data showed that dietary PG have profound effects on hepatic insulin sensitivity and oxidative stress, two key factors in the pathogenesis of NAFLD, demonstrating the potential of PG as a therapeutic strategy for NAFLD.Funding Information
- Beijing Municipal Science and Technology Commission (D16110500540001)
This publication has 41 references indexed in Scilit:
- Prevalence, incidence, and outcome of non-alcoholic fatty liver disease in Asia, 1999–2019: a systematic review and meta-analysisThe Lancet Gastroenterology & Hepatology, 2019
- Global burden of NAFLD and NASH: trends, predictions, risk factors and preventionNature Reviews Gastroenterology & Hepatology, 2017
- Non-Alcoholic Fatty Liver DiseasePublished by Springer Science and Business Media LLC ,2017
- Caulerpa lentillifera extract ameliorates insulin resistance and regulates glucose metabolism in C57BL/KsJ-db/db mice via PI3K/AKT signaling pathway in myocytesJournal of Translational Medicine, 2015
- Association Between Insulin Resistance and Oxidative Stress Parameters in Obese Adolescents with Non-Alcoholic Fatty Liver DiseaseJournal of Clinical Research in Pediatric Endocrinology, 2013
- Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent modelJournal of Hepatology, 2010
- Insulin resistance and oxidative stress interdependency in non-alcoholic fatty liver diseaseTrends in Molecular Medicine, 2006
- Regulation of pancreatic β-cell growth and survival by the serine/threonine protein kinase Akt1/PKBαNature Medicine, 2001
- Steatohepatitis: A tale of two “hits”?Gastroenterology, 1998
- Insulin-Stimulated GLUT4 Translocation Is Relevant to the Phosphorylation of IRS-1 and the Activity of PI3 KinaseBiochemical and Biophysical Research Communications, 1993