Selective C‐alkylation Between Alcohols Catalyzed by N‐Heterocyclic Carbene Molybdenum
- 16 September 2021
- journal article
- research article
- Published by Wiley in Chemistry – An Asian Journal
- Vol. 16 (20), 3124-3128
- https://doi.org/10.1002/asia.202100959
Abstract
The first implementation of a molybdenum complex with an easily accessible bis-N-heterocyclic carbene ligand to catalyze β-alkylation of secondary alcohols via borrowing-hydrogen (BH) strategy using alcohols as alkylating agents is reported. Remarkably high activity, excellent selectivity, and broad substrate scope compatibility with advantages of catalyst usage low to 0.5 mol%, a catalytic amount of NaOH as the base, and H2O as the by-product are demonstrated in this green and step-economical protocol. Mechanistic studies indicate a plausible outer-sphere mechanism in which the alcohol dehydrogenation is the rate-determining step.Keywords
Funding Information
- National Natural Science Foundation of China (21973113, 21977019)
- Fundamental Research Funds for the Central Universities
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